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Lifeflower® Breviscapine Bioavailable Vegetarian Capsules

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U.S. Patent #6084080

BREVISCAPINE

  • Increases cerebral blood flow*
  • Promotes the permeability of blood-brain barrier*
  • Improves nutritional blood flow of myocardium*
  • Supports immune function*
  • Promotes angiogenesis*
  • Improves memory*
  • Therapeutic effects in cardiovascular and cerebrovascular accidents*
  • Neuroprotective against cerebral ischemia apoptosis*
  • Protective on ischemic vascular dementia*

WHAT IS BREVISCAPINE?

Breviscapine (Scutellarin) is a natural compound extracted from Erigeron Breviscapus (Vant.) Hand.-Mazz., which is a Chinese herbal medicine that has been in use for the treatment of paralysis, rheumatism, gastritis, toothache, and fever for more than 600 years. It can quickly cross blood-brain barrier, increases blood supply in brain, promotes angiogenesis, improves memory. Recent studies suggest that Breviscapine has therapeutic effects in cardiovascular and cerebrovascular accidents, also is neuroprotective against cerebral ischemia apoptosis and ischemic vascular dementia. It’s an odorless, tasteless light yellowish powder that can be added to capsules, tablets, liposome, powder and liquid. Breviscapine is GRAS affirmed.*

WHY BREVISCAPINE?

Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus.

Our breviscapine contains more than 98% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply.

The use of breviscapine for the treatment of hypertension, cerebral embolism, and paralysis due to cerebrovascular accident dates back to the 1970s. Recent studies have suggested that breviscapine can be used to treat cerebral infarction and diabetic nephropathy.*

ACTIVE COMPOUNDS IN BREVISCAPINE

FLAVONOID

Scutellarin

As the primary active ingredient in Breviscapine, scutellarin’s (4′,5,6,7-tetrahydroxyflavone-7-O-glucuronide) increases cerebral blood flow. Studies have shown that it raises permeability of blood-brain barrier, increases nutritional blood flow of myocardium, raises immune function of body macrophage cell and counteraction against blood and oxygen depletion induced by hypophyseal pituitrin and thrombocyte agglutination.*

Apigenin
Apigenin is found to have protective effect of adult neurogenesis and for the treatment of neurological diseases, disorders and injuries, by stimulating the generation of neuronal cells in the adult brain.
In addition, Apigenin readily crosses the blood-brain barrier and has not demonstrated toxicity at high doses. It could thus prevent amyloid beta deposition and tau phosphorylation due to neuroinflammation, which can lead to Alzheimer's disease.*

WHY FARLONG® LIFEFLOWER® BREVISCAPINI™:

Farlong® Lifeflower® Breviscapini™ is a patented pharmaceutical grade Breviscapine.*

U.S. Patent No.:6084080; China Patent No.: ZL 2011 1 0277789.1; ZL 2009 1 0163211.6.

QUALITY CONTROL from SEED-TO-SALE TRACEABILITY

GAP Cultivation

GMP Manufacturing

GSP Logistic & Warehousing

Third Party Laboratory Verified

FDA Compliance

Quality & Safety Guarantee

SCIENTIFIC EVIDENCE

Human and animal clinical trials and toxicity studies of breviscapine have been completed to show the clinical results for the treatment of cerebral ischemia stroke, coronary heart disease or pectoris.*

A study titled “Post-marketing Safety Surveillance of Breviscapine Powder-Injection: a Registry Study” by Zhong Wang from China Academy of Chinese Medial Sciences has started in September 2015 and is currently in progress with 20,000 subjects enrolled.

PUBLICATIONS

  • Wang, WW et al. "Scutellarin May Alleviate Cognitive Deficits in a Mouse Model of Hypoxia by Promoting Proliferation and Neuronal Differentiation of Neural Stem Cells.". Iran J Basic Med Sci 20.3 (2017): 272-279.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378964/

  • Zhong, Haijun et al. "Multivesicular Liposome Formulation for the Sustained Delivery of Breviscapine". International Journal of Pharmaceutics 301.1-2 (2005): 15-24.

https://www.ncbi.nlm.nih.gov/pubmed/16023316

  • Xia, Qing-jie et al. "Breviscapine Reduces Neuronal Injury Caused by Traumatic Brain Injury Insult: Partly Associated with Suppression of Interleukin-6 Expression". Neural Regeneration Research 12.1 (2017): 90.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319248/

  • Pengyue, Zhang et al. "Breviscapine Confers a Neuroprotective Efficacy against Transient Focal Cerebral Ischemia by Attenuating Neuronal and Astrocytic Autophagy in the Penumbra". Biomedicine & Pharmacotherapy 90 (2017): 69-76.

https://www.ncbi.nlm.nih.gov/pubmed/28343073

  • Yiming, Liu et al. "Neuroprotective Effects of Breviscapine against Apoptosis Induced By Transient Focal Cerebral Ischaemia in Rats". Journal of Pharmacy and Pharmacology 60.3 (2008): 349-355.

https://www.ncbi.nlm.nih.gov/pubmed/18284815

  • Wang, Wenjuan et al. "Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor". PLOS ONE 11.1 (2016): e0146197.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711585

  • Fox News Health – Lifeflower: A Treatment for stroke

http://www.foxnews.com/health/2011/01/17/lifeflower-treatment-stroke.html

  • Research Advance on Cardiovascular Pharmacological and Clinical Application of Breviscapinum

http://en.cnki.com.cn/Article_en/CJFDTOTAL-YYGZ200721003.htm

  • Breviscapinum has the pharmacological effects such as increasing the blood flux, improving the microcirculation, dilating the blood vessel, antithrombus and so on.

http://dict.cn/Breviscapinum%20has%20the%20pharmacological%20effects%20such%20as%20increasing%20the%20blood%20flux%2Cimproving%20the%20microcirculation%2Cdilating%20the%20blood%20vessel%2Cantithrombus%20and%20so%20on_2E

  • Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats.

https://www.ncbi.nlm.nih.gov/pubmed/18284815

  • Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats.

https://www.ncbi.nlm.nih.gov/pubmed/17878763

  • Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review

http://journal.frontiersin.org/article/10.3389/fphar.2017.00289/full

  • Post-marketing Safety Surveillance of Breviscapine Powder-Injection : a Registry Study

https://clinicaltrials.gov/ct2/show/NCT02559960

*Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, treat, or prevent any disease.



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