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June 09, 2020

Pharmacodynamics by

Scutellarin, from E. breviscapus, suppressed proliferation and promoted apoptosis in cisplatin-reistant adenocarcinoma A549 cells through AKT/mTOR/4EBP1 and STAT3 pathways. Cao 2019

Scutellarin, from E. breviscapus, cmarkedly inhibited the invasive potential of melanoma cell lines by suppressing the EMT and angiogenesis through the PI3K/Akt/mTOR signaling pathway. Li 2019


Systematically deciphered the mechanisms of E. breviscapus for treating cerebrovascular disease (CBVDs) using systems pharmacology approach. E. breviscapus exerts a protective effect on CBVDs via regulating multiple pathways and hitting on multiple targets. Wang 2018


Scutellarin, from E. breviscapus, inhibited human hepatocellular carcinoma cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling. Ke 2017


Scutellarin, from E. breviscapus, inhibited platelet adhesion and aggregation induced by multiple G protein coupled receptor agonists, in rat washed platelets. It's role as a potential protein kinase C (PKC) inhibitor was confirmed by PKC activity analysis and molecular docking. Tian 2016


Scutellarin, from E. breviscapus, modulated ischemia-reperfusion injury-induced oxidative stress and apoptosis in rat cardiomyoblast cells H9C2, probably by enhancing JAK2/STAT3 pro-survival signaling. Wang 2016


Scutellarin, the representativebioactive flavonoid isolated from E. breviscapus, significantly inhibited the metabolism of clopidogrel, and affected its pharmockinetics, in rat liver microsomes, in vitro. Chen 2015


Pretreatment with scutellarin, from E. breviscapus, significantly inhibited the decrease in cell viability of human cardiac microvascular endothelial cells against hypoxia-reoxygenation injury. Identified proteins that may play an important roles in these effects. Shi 2015


Scutellarin, a flavonoid from Erigeron breviscapus and other plants, blocked the inflammatory response by directly inhibiting Src kinase activity linked to NF-κB activation, as observed in a variety of in vitro assays. Sung 2015


DSX from Erigeron breviscapus reversibly and dose-dependently suppressed outward K(+) channel currents in rat rat retinal ganglion cells, which may be one of the possible mechanisms underlying Erigeron breviscapus ability to prevent vision loss and RGC damage caused by glaucoma. Yin 2015


Scutellarin and the caffeic acid fraction of E. breviscapus extract upregulated neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytes through p-CREB and p-Akt signaling, which suggests a neuroprotective effect. Chai 2013


Erigeron breviscapus inhibited the expression of OPG in osteoblasts in a dose- and time-dependent manner, promoted the expression of RANKL in osteoblasts and the secretion of RANK in pre-osteoclast, indicating EB might play roles in promoting bone resorption. [Article in Chinese] Liu 2013


In proteasomes from mice and cancer cells, baicalin and scutellarin from Scutellaria baicalensis and Erigeron breviscapus specifically inhibited chymotrypsin-like catalytic activity. Wu 2013


Scutellarin, from E. breviscapus, diminished proliferation of B-lymphoma Namalwa cells in vitro and inhibited lymphoma growth in Namalwa cell-xenotransplanted mice without obvious toxicity. Mechanisms explored. Feng 2012


MRC-5 cultured cells treated with E. breviscapus under hypoxia condition exhibited significantly reduced expression of pro-collalpha1, p-smad2, HIF-1alpha in MRC-5 cells and collagen type I, MMP1, TIMP1 in supernatant fluid. [Article in Chinese] Zheng 2012


Scutellarin, from E. breviscapus, inhibited MUC5AC expression both in mRNA and protein level induced by human neutrophil elastase in a concentration-dependent manner in human bronchial epithelial 16 (HBE16) cells. However, it failed to inhibit MUC5AC mucin production induced by IL-13. Jiang 2011


In vitro study of rat primary microglia and mouse microglial cell lines showed that scutellarin, from E. breviscapus, had an anti-inflammatory effect in microglial cells which contributed to its neuroprotective activity. Underlying mechanisms explored. Wang 2011


Scutellarin, from E. breviscapsu, promoted angiogenesis in human umbilical vein endothelial cells, and induced MMP-2 activation and mRNA expression in a concentration dependent manner. Gao 2010


Scutellarin, from E. breviscapus, sensitized resveratrol-and 5-fluorouracil-evoked apoptosis in wild-type (p53+/+) but not knockout (p53(-/-)) HCT116 human colon cancer cells. It promoted resveratrol and 5-fluorouracil-elicited caspase-6 activation. Chan 2009


(2Z,8Z)-Matricaria acid methyl ester isolated from the methanol extract of Erigeron breviscapus is a novel inhibitor of melanin biosynthesis. It demonstrated strong whitening activity in B16F10 melanoma cells. Luo 2009


Scutellarin, a major flavone derived from E. breviscapus showed estrogenic effects in MCF-7 cells in a dose-dependent manner and inhibited the aggregation of beta-amyloid and prevented cell death in neruonal PC12 cells. Zhu 2009


Erigeron breviscapus ethanol extract, its ethyl acetate fraction and aqueous fraction, significantly inhibited GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSDAH). Baicalein was the most potent inhibitor for GABA-T. Scutellarein exhibited the best inhibitory effect on SSADH. Tao 2008


Breviscapine, from E. breviscapus, showed effective activity on scavenging DPPH, superoxide anion radicals and nitric oxide. At the highest concentration of breviscapine, the inhibition extent of lipid peroxidation induced by Fe(2+) in rat liver homogenates was 38.5%. Wang 2008


In a neuron oxidative injury model induced by superoxide radical, the ethanol extract of Erigeron breviscapus reduced the lipid peroxidation levels and lactic dehydrogenase released from the neurons, suggesting neuroprotective actions due to antioxidant activity. Liu 2005


Scutellarin from Erigeron breviscapus inhibited several strains of HIV-1 replication by inhibiting HIV-1 RT activity, HIV-1 particle attachment, and cell fusion. Zhang 2005


Culturing rat retinal neurons with caffeic acid, seopoletin, and scutellarin (from E. breviscapus) increased the number of living cells compared to control.[Article in Chinese] Zhang 2005


An ethanol extract of Erigeron breviscapus whole plant showed a moderate antibacterial activity and a high antifungal activity. Liu 2003


Erigeron breviscapus extract significantly delayed coagulation time and prothrombin time, inhibited platelet factor III activity, and decreased euglobulin lysis time.[Article in Chinese] Wang 2003


The defective endothelium-dependent relaxation in diabetic rat aorta occurred as early as 2-wks' duration of diabetes, and Erigeron breviscapus could protect vascular endothelium, in vitro. The deficits in vascular smooth muscle contractile responses were not protected. Zhu 1999


A study on the effects of 18 Chinese herbs on the synthesis of TXA2 and PGI2 found that Erigeron breviscapus significantly inhibited the synthesis of TXA2 but not PG12 in porcine lung microsoma. [Article in Chinese] Wang 1993


New breviscapine exerted differential effects on the arachidonic acid metabolism in different blood cells and endothelial cells. Wang 1993


New-breviscapine, a flavonoid extracted from E. breviscapus, stimulated fibrinolysis and anticoagulation in cultured confluent human umbilical vein endothelial cells. Zhou 1992


An experimental study on the anti-reoxidation injury on myocardium of Erigeron breviscapus. [No abstract][Article in Chinese] Xie 1990