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June 09, 2020

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Results from in vivo mouse studies and in vitro studies in h22 ascites cells suggested that scutellarin, a flavone extracted from E. breviscapus, could enhance the anti-tumor effect of bleomycin and reduce bleomycin-induced pulmonary fibrosis. Nie 2018


Scutellarin, flavone extracted from E. breviscapus reversed cisplatin resistance in non-small cell lung cancer A549/DDP cells through apoptosis and autophagy. Results suggested synergistic therapy may be a novel therapeutic strategy. Sun 2018


Dengzhan Shengmai capsule, consisting of Erigeron breviscapus, Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis, significantly affected the pharmacokinetics of clopidogrel, as studied in rats and MDCKII-MDR1 cells, necessitating caution when co-administering in the clinic. Chen 2016


A comparison of the inhibition potential of scutellarin and scutellarein, important bioactive flavonoids extracted from E. breviscapus, toward several liver UDP-glucuronosyltransferase isoforms, including UGT1A1, UGT1A6, UGT1A9 and UGT2B7. Ma 2014


Concurrent use of valsartan reduces the biliary excretion of scutellarin (from E. breviscapus) which may be due to its inhibitory effect on excretion mediated by Mrp2. Possible explanation of enhanced protection against diabetic nephropathy offered by the combination. Cui 2013