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Pharmacodynamics (172)

June 08, 2020

Pharmacodynamics by PubMed.gov

A TCM compound including Panax notoginseng saponins exhibited a protective effect against LPS-induced inflammation and cisplatin-induced kidney toxicity via inhibiting inflammation through downregulation of Mincle pathway in macrophages. Hui 2020

 

MiR-30c-5p mediates the effects of Panax notoginseng saponins in myocardial ischemia reperfusion injury in rats by inhibiting oxidative stress-induced cell damage in cardiomyocytes. Wang 2020

 

Panax notoginseng saponins prevented senescence and inhibited apoptosis of articular cartilage by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes. Zhang 2020

 

Panax notoginseng saponin inhibited balloon injury-induced vascular smooth muscle cell proliferation and migration and intimal hyperplasia via regulating WTAP/p16 signals via m6A modulation. Zhu 2020

 

Panax notoginseng exhibited a concentration-dependent protective effect against thapsigargin-induced ER stress response and associated cell apoptosis in cardiac myocytes via mediating intracellular calcium. Chen 2019

 

Notoginsenoside R1, a saponin from Panax notoginseng, exhibited a protective effect against lipopolysaccharide-induced inflammation injury in lung fibroblast MRC-5 cells via upregulating microRNA-132 and inactivating NF-κB and JNK pathways. Cong 2019

 

Panax notoginseng saponins and catalpol were shown to exhibit isolated and synergistic activity against triptolide-induced hepatotoxicity in human hepatocytes via the nuclear factor erythroid-2-related factor-2 (Nrf2)/antioxidant response element (ARE) pathway. Feng 2019

 

Notoginsenoside R1, a saponin from Panax notoginseng, provided protection against oxygen and glucose deprivation-induced injury in cardiomyocytes via upregulation of miR-21, repressing the expression of target phosphatase and tensin homolog and preventing blockage of PI3K/AKT signaling pathway. Liu 2019

 

Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) was shown to provide a useful means for exploring biomarkers involved in alcoholic fatty liver and elucidating the therapeutic effects of leaves of Panax notoginseng saponins. Liu 2019

 

Ginsenoside Rk3, a saponin from Panax notoginseng, inhibited Eca109 and KYSE150 cell proliferation via activating apoptosis and autophagy by blocking the PI3K/Akt/mTOR pathway, which may be beneficial in the treatment of esophageal cancer. Liu 2019

 

Notoginsenoside R1, a saponin from Panax notoginseng, was found to provide a protective effect against lipopolysaccharide-stimulated inflammatory damage in human renal proximal tubular epithelial cells at least partially by upregulation of miR-26a and inactivation of the NF-κB pathway. Liu 2019

 

Panax notoginseng was found to attenuate oxygen and glucose deprivation/reoxygenation-induced injury in human undifferentiated SH-SY5Y cells by regulating the expression of inflammatory factors via miR-155. Meng 2019

 

A network pharmacology study identified 10 pain disease proteins and 45 therapeutic targets for pain attenuation in Fufang Dashen, a Traditional Chinese Medicine that includes Panax notoginseng. Sun 2019

 

Panax notoginseng extract significantly inhibited growth of Streptococcus pyogenes, Streptococcus pneumoniae, and Haemophilus influenzae; however, it did not affect growth of oral commensal bacteria Streptococcus intermedius, Streptococcus salivarius, and Streptococcus anginosus. Wajima 2019

 

Panax notoginseng saponins were found to improve the biomechanical stability of the cytoskeleton of single human umbilical vascular endothelium cells during oxidative damage. Zhang 2019

 

Nine dammarane-type saponins from Panax notoginseng were evaluated for neuroprotective activity against glutamate-induced neurotoxicity in PC12 cells, with protopanaxatriol exhibiting the highest neuroprotective effect via various mechanisms of action. Zhang 2019

 

Ginsenoside Rg1, a saponin from Panax notoginseng, attenuated high glucose-induced endothelial barrier dysfunction in human umbilical vein endothelial cells by attenuating the associated increase in heparanase expression and protecting the endothelial glycocalyx. Zhu 2019

 

Panax notoginseng saponin R1 was found to alleviate dexamethasone-induced apoptosis in bronchial epithelial cells via inhibition of the mitochondrial apoptosis pathway, which may be beneficial in the treatment of asthma. Zou 2019

 

Panaxydol, a polyacetylene isolated from Panax notoginseng, was found to elicit axonal growth in PC12 cells via the cyclic adenosine 3',5'-monophosphate (cAMP)-Epac1-Rap1-MEK-ERK-CREB pathway, independent of protein kinase A. Li 2018

 

Panax notoginseng saponins was found to dose-dependently promote macrophage M2-polarization under hyperglycemic conditions via downregulating the NF-κB signaling pathway. Zhao 2018

 

Panax notoginseng saponins exhibited a protective effect against high glucose-induced injury in rat retinal capillary endothelial cells, which may be partially attributed to its antioxidative function. Fan 2016

 

Panax notoginseng saponin and and notoginsenoside R1 were found to regulate immune response in endothelial cells challenged with PRRSV via modulating production of interleukin-4 (IL-4) and IL-10. Hu 2016

 

20(S)-protopanaxadiol saponins from Panax notoginseng were found to inhibit SKOV3 human ovarian cancer cell migration, reducing the expression of osteopontin, a glycophosphoprotein cytokine frequently expressed in ovarian carcinoma effusions. Li 2016

 

Notoginsenoside R1, an active saponin from Panax notoginseng, dose-dependently was found to promote osteoblastogenesis in MC3T3-E1 pre-osteoblast cells, which may be beneficial in bone regeneration. Liu 2016

 

Panax notoginseng exhibited a protective effect against CoCl2-induced apoptosis of rat bone marrow mesenchymal stem cells via improving cell mitochondrial membrane potential, up-regulating expressions of Bcl-2 and Bcl-xl, and reducing the Bax/Bcl-2 gene expression ratio. [Article in Chinese] Ou 2016

 

Panax notoginseng panaxatriol saponins were shown to be effective in anti-platelet aggregation, at least in part to the suppression of intracellular calcium mobilization and ERK2/p38 activation. Qi 2016

 

Panax notoginseng saponins were found to promote rat embryonic cortical neuronal stem cell survival, self-renewal, proliferation, and differentiation through neurotrophic factors by autocrine or paracrine signaling. Si 2016

 

Notoginsenoside-R1, an active saponin from Panax notoginseng, was found to suppress oxLDL-induced inflammatory cytokines production in vascular endothelial cells via activating PPARγ, which inhibited oxLDL-induced NF-κB and MAPK activation. Su 2016

 

Panax notoginseng saponins were found to exhibit a neuroprotective effect against palmitate-triggered endoplasmic reticulum stress-associated apoptosis and loss of postsynaptic protein in staurosporine differentiated RGC-5 retinal ganglion cells. Wang 2016

 

Panax notoginseng saponins exhibited superior activity to aspirin in inhibiting platelet adhesion to injured endothelial cells, possibly by regulating the cyclooxygenase pathway. Wang 2016

 

Panax notoginseng saponins exhibited time- and dose-dependent significant protective effects against 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells, possibly via activation of Nrf2, up-regulation of HO-1, and inhibition of oxidative stress. [Article in Chinese] Wang 2016

 

Panax notoginseng extract exhibited a protective effect against replicative senescence of human aortic smooth muscle cells, significantly reducing the protein expression of F-actin and the formation of stress fibers. [Article in Chinese] Xiu 2016

 

Mechanisms of Panax notoginseng in treating coronary heart disease may be related to anticoagulant and hypolipidemic activity as indicated by GeneMANIA Cytoscape and Advanced Network Merge gene functional enrichment analysis. Yu 2016

 

Panax notoginseng total saponins promoted differentiation of DCX(+) cells expressing immature neuroblasts in the olfactory bulb following global brain ischemia/reperfusion via activation of the signaling pathway of cyclic adenosine monophosphate response element binding protein. He 2015

 

Panax notoginseng saponins may stimulate osteogenesis processes and osteoblastic proliferation, differentiation, and mineralization by increasing cellular ALP activity, extracellular matrix mineralization, and osteoblast-associated molecules in osteoblasts. Ji 2015

 

Panax notoginseng saponins were shown to significantly inhibit proliferation, promote apoptosis, and cause cell cycle arrest in G0/G1 phase in K562 cells, possibly by up-regulating cleaved caspase 3 and down-regulating cyclin D1 and the mTOR signaling pathway. [Article in Chinese] Li 2015

 

Panax notoginseng saponins dose-dependently attenuated Notch3 silencing-induced phenotype switching of vascular smooth muscle cells, which may be beneficial in atherosclerotic disease. Liu 2015

 

Panax notoginseng flower saponins inhibited lipopolysaccharide-stimulated NO overproduction and iNOS gene overexpression in RAW264.7 macrophages via suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways but not the PI3K/Akt signaling pathway. Peng 2015

 

Panax notoginseng was shown to significantly inhibit TGF-beta1-induced fibrotic activity in A549 human alveolar epithelial cells by inhibiting epithelial to mesenchymal transition. [Article in Chinese] Ren 2015

 

Ginsenoside R1, an active saponin from Panax notoginseng, was found to stimulate osteogenic differentiation and promote the mineralization process of cultured osteoblasts by activating estrogen receptors signaling. Wang 2015

 

Panax notoginseng saponins were found to promote proliferation and migration of anterior cruciate ligament fibroblasts and to increase the expression levels of collagen and fibronectin, effects associated with phosphorylation of PI3K, AKT, and ERK. Yu 2015

 

Notogensenoside Rb1, an active saponin from Panax notoginseng, exhibited anti-oxidative activity against H2O2 oxidative stress-induced endoplasmic reticulum stress in cultured PC12 cells by inducing Trx-1 expression. Zeng 2015

 

Notoginsenoside R1, an active saponin from Panax notoginseng, exhibited anti-inflammatory and anti-apoptotic effects on H9c2 cardiomyocytes via estrogen-receptor mediation. Zhong 2015

 

Panax notoginseng saponins concentration-dependently inhibited areca nut extract-induced oral submucous fibrosis in vitro, possibly inhibiting activation of PI3K/AKT, ERK/JNK/p38 MAPK, and TGFβ/smad pathways in oral mucosal fibroblasts. Dai 2014

 

Notoginsenoside Ft1, a saponin isolated from Panax notoginseng, was found to dose-dependently induce platelet aggregation by activating a signalling network mediated through P2Y₁₂ receptors. Gao 2014

 

Notoginsenoside Ft1, isolated from Panax notoginseng, was found to arrest the proliferation and to elicit apoptosis of SH-SY5Y neuroblastoma cells, possibly via p38 MAPK and ERK1/2 pathways. Gao 2014

 

Among six dammarane-type saponins isolated and characterized from steamed Panax notoginseng and subsequently screened for anti-tumor activity against human kidney 293T carcinoma, ginsenoside Rb3 exhibited the most significant activity with an IC50 of 8.2 μM. He 2014

 

Flavonoids from Panax notoginseng flowers were shown to exhibit radical scavenging activities as well as antimicrobial inhibitory effects on Staphylococcus aureus, Aeromonas hydrophila, and Pseudomonas aeruginosa. Hong 2014

 

Panaxatriol saponins, isolated from Panax notoginseng, were found to activate an endogenous cytoprotective mechanism against oxygen-glucose deprivation injury in PC12 cells, possibly by activation of PI3K/Akt and Nrf2 signaling pathways. Huang 2014

 

Trilinolein from Panax notoginseng exhibited anti-inflammatory activity in a lipopolysaccharide-stimulated mouse macrophage and carrageenan-induced mouse paw edema models which may be related to decreases in iNOS, COX-2, IκBα, and the MAPK pathway through the suppression of TNF-α, IL-1β, and IL-6. Huang 2014

 

Panax notoginseng total saponins reduced D-galactose-induced H9c2 cell senescence via improving antioxidant capability and attenuating apoptosis. [Article in Chinese] Li 2014

 

Notoginsnoside R1, isolated from Panax notoginseng, counteracted the effects of amyloid-β in cultured neurons by increasing cell viability, reducing oxidative damage, restoring mitochondrial membrane potential, and suppressing stress-activated MAPK signaling pathways. Ma 2014

 

Notoginseng Rg1, a saponin from Panax notoginseng, exhibited a neuroprotective effect against oxidative stress in PC12 cells via inducing estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways and activating Nrf2/ARE signaling and thereby up-regulating phase II antioxidant enzymes. Meng 2014

 

Gypenoside, a phytoestrogen flavonoid from Panax notoginseng, attenuated amyloid-beta 25-35-induced parallel autophagic and apoptotic cell death in PC12 cells via estrogen receptor-dependent activation of PI3K/Akt pathways, inactivation of GSK-3β ,and activation of Nrf2/ARE/HO-1 pathways. Meng 2014

 

Panax notoginseng leaf saponins were found to reduce H2O2-induced cell death in primary rat cortical astrocytes and to protect against oxygen and glucose deprivation/reoxygenation-induced human neuroblastoma cell damage, effects associated with attenuation of reactive oxygen species. Zhou 2014

 

Ginsenoside Rg6 from Panax notoginseng was found to dose-dependently inhibit JK cell proliferation and induce apoptosis in human lymphocytoma, possibly by promoting mitochondrial dysfunction and increasing Bax expression and decreasing Bcl-2 expression. Chen 2013

 

Ginsenoside F4 from steamed Panax notoginseng was found to promote apoptosis in human lymphocytoma cells, an effect associated with mitochondrial dysfunction and the increase of Bax expression and decrease of Bcl-2 expression. Chen 2013

 

Panax notoginseng aqueous extract, as well as ginsenosides Rg1 and Rg2, significantly extended blood clotting time in human plasma. Li 2013

 

Notoginsenoside R2, a saponin from Panax notoginseng, exhibited neuroprotective activity against 6-hydroxydopamine-induced oxidative stress and apoptosis in SH-SY5Y cells, effects associated with P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways. Meng 2013

 

Panax notoginseng triterpenes were found to concentration-dependently promote EA-hy926 cell proliferation, angiogenesis, and expression of vascular endothelial growth factor. Shi 2013

 

Panax notoginseng was found to inhibit TLR ligand- and interferon gamma-induced murine N9 and EOC20 microglial cell activation independent of the glucocorticoid receptor nor as the result of a single ginsenoside. Beamer 2012

 

Panax notoginseng saponins was found to stimulate bone formation by promoting the proliferation and differentiation of BMSCs and to protect the skeletal system by decreasing bone resorption through reduction of RANKL/OPG expression via Wnt/β-catenin signaling pathways. Chen 2012

 

Panax notoginseng saponins were found to exhibit dose- and time-dependent cytotoxicity and antiproliferative activity against the human colon cancer cell line LoVo, causing cell cycle arrest at S phase, as well as to possess free radical scavenging activity. He 2012

 

Ginsenoside Rg1, an active saponin from Panax notoginseng, was found to inhibit transient receptor potential vanilloid-1 (TRPV1) activation in keratinocyte HaCat cells and to dose-dependently inhibit capsaicin-induced PGE(2) and IL-8 secretion in HaCaT and HEK 293T-TRPV1 cells. Huang 2012

 

Ginsenoside-Rd from Panax notoginseng significantly concentration-dependently potentiated hydrogen peroxide-induced cell death and apoptosis in basilar artery smooth muscle cells via the mitochondria-dependent pathway. Li 2012

 

Notoginsenoside Ft1 from Panax notoginseng was found to stimulate angiogenesis in human umbilical vein endothelial cells via upregulating HIF-1α-mediated VEGF expression and regulating PI3K/AKT and Raf/MEK/ERK signaling cascades. Shen 2012

 

Panax notoginseng, in formulation with Radix Ginseng and Rhizoma Chuanxiong, delayed senescence of vascular smooth muscle cells by significantly altering the p16-cyclinD/CDK-Rb pathway. Tao 2012

 

Panax notoginseng saponins were found to dose-dependently promote proliferation and differentiation in NIH3T3 cells by up-regulation of P-ERK1/2 protein kinase. Yin 2012

 

Panax notoginseng saponins were found to inhibit vascular smooth muscle cell proliferation by inhibiting activation of the extracellular regulated protein kinase (ERK) signal transduction pathway. Zhang 2012

 

Trilinolein, an active component of Panax notoginseng, was found to time and dose dependently inhibit proliferation of human non-small cell lung carcinoma A549 via modulation of Bcl-2 and caspase-3, which are associated with cytochrome c release and dephosphorylation on the Akt signaling pathway. Chou 2011

 

Panax notoginseng n-butanolic extract was found to suppress lipopolysaccharide (LPS)-induced MMP-2 expression in periodontal ligament fibroblasts and to inhibit osteoclastogenesis by suppressing MAPK in LPS-activated RAW264.7 cells. Jang 2011

 

Panax notoginseng root and flower extracts were found to inhibit the quorum-sensing ability of Chromobacterium violaceum and Pseudomonas aeruginosa biofilm formation. Koh 2011

 

Panax notoginseng saponins were found to promote osteogenic differentiation of bone marrow stromal cells by activating the ERK and P38 MAPK signaling pathways. Li 2011

 

Notoginsenoside ST-4, a novel dammarane-type saponin from steamed Panax notoginseng, was found to inhibit virus penetration of herpes simplex virus types 1 and 2 in Vero cells. Pei 2011

 

Panax notoginseng saponins promoted proliferation and differentiation of hippocampus neural stem cells after oxygen glucose deprivation by inducing expression of nestin/BrdU and enhancing class III β-tublin, vimentin, and nestin mRNA. Si 2011

 

Panaxydol, a saponin from Panax notoginseng, was found to induce differentiation of human liver carcinoma cells by decreasing the expression of regulatory factors Id1 and increasing the protein levels of p21 and p-ERK1/2. Wang 2011

 

Panax notoginseng saponin fractions and major individual ginsenosides were found to exhibit anti-atherogenic effects against recombinant human tumor necrosis factor-α-induced monocyte adhesion, as well as the expression of adhesion molecules, in vitro and in vivo. Wang 2011

 

25-OCH(3)-PPD, a dammarane-type triterpene sapogenin isolated from the roots, leaves and seeds of Panax notoginseng, was found to induce apoptosis of activated t-HSC/Cl-6 cells via c-FLIP-mediated NF-κB activation. Wu 2011

 

Pretreatment with Panax notoginseng saponins was found to inhibit proliferation of platelet-derived growth factor and to induce apoptosis in rat vascular smooth muscle cells via upregulating p53, Bax, and caspase-3 expressions and downregulating Bcl-2 expression. Xu 2011

 

Panaxynol and panaxydol, two active saponins from Panax notoginseng, were found to time- and dose-dependently induce apoptosis in human promyelocytic leukemia HL60 cells. Yan 2011

 

Quercetin 3-O-beta-D-xylopyranosyl-beta-D-galactopyranoside isolated from Panax notoginseng roots was found to reduce brain damage in scopolamine-treated rats as well as to time and dose dependently reduce amyloid-beta-induced neurotoxicity in cultured neurons. Choi 2010

 

An aqueous extract of Panax notoginseng flower was found to exhibit neuroprotective effects on neuronal PC12 cells by inhibiting the enzymatic activity of xanthine oxidase and reducing H2O2-induced cytotoxicity. Choi 2010

 

Panax notoginseng extract was found to be effective in scavenging OH and O(2-), while showing low activity in the DPPH assay. Han 2010

 

Panax notoginseng saponins significantly dose-dependently decreased cholesterol ester via up-regulating ATP-binding cassette transporter A1 in macrophage-derived foam cells by agonizing liver X receptor α. Jia 2010

 

Panax notoginseng saponins flowers were found to exhibit dose-dependent inhibition of tumor cell-induced platelet aggregation (TCIPA) of MDA-MB-231 breast carcinoma in vitro and in vivo. Saponins from rhizomes inhibited TCIPA at a high dose in vivo. [Article in Chinese] Ke 2010

 

A combination Radix notoginseng and Radix ginseng formula was found to dose-dependently promote human umbilical vascular endothelial cell proliferation and secretion of VEGF, as well as the expression of VEGFR-2 protein, which may be a mechanism in promoting angiogenesis. [Article in Chinese] Lei 2010

 

Panax notogiseng saponins were found to promote osteogenesis of bone marrow stromal cells by targeting osteogenesis-associated genes, which could be mediated by their actions on gap junction intercellular communication. Li 2010

 

Panax notoginseng saponins were found to dose dependently exhibit a protective effect against hydrogen peroxide-induced apoptosis in cultured rabbit bone marrow stromal cells by decreasing oxidative stress, Bax expression, and caspase-3 activity. Qiang 2010

 

Pretreatment with Panax notoginseng saponins was found to provide a concentration-dependent protective effect against oxidative stress-induced damage and apoptosis in cultured rabbit bone marrow stromal cells via scavenging ROS and regulating the Bcl-2/Bax pathway. Qiang 2010

 

Panax notoginseng was found to increased protein expression of angiogenesis signaling pathway proteins VEGFR-2-Ras-MAPK in human umbilical vein endothelial cells. [Article in Chinese] Tian 2010

 

Ginsenoside Rb3 from Panax notoginseng exhibited a dose-dependent protective effect against oxygen and glucose deprivation-Rep induced ischemic injury in PC12 cells, possibly by suppressing intracellular Ca(2+) elevation and inhibiting apoptosis and caspase activity. Zhu 2010

 

The dammarane-type triterpene sapogenin (20(S)-25-OCH3-PPD) from Panax notoginseng inhibited proliferation and induced apoptosis in human lung and colon cancer cell lines, significantly reducing expression of beta-catenin, a key mediator in the Wnt pathway. Bi 2009

 

The cardiac therapeutic effects of Panax notoginseng were found to be partly due to the effective inhibition of Na+/K+-ATPase by their metabolized ginsenosides with sugar moieties attached only to the C-3 position of the steroid-like structure. Chen 2009

 

Notoginsenoside R1, an active saponin from Panax notoginseng, exhibited a protective effect against glutamate-induced neurotoxicity in primary cultured mouse cortical neurons, possibly by inducing expression of N-methyl-D-aspartate receptors composed of NR1/NR2B subunit assembly. Gu 2009

 

Phosphatidylinositol 3-kinase activity was found to be involved in panaxydiol-induced growth inhibition and differentiation of rat C6 glioma cells. Hai 2009

 

Panax notoginseng was shown to promote angiogenesis in human umbilical vein endothelial cells and zebrafish by modulating vascular endothelial growth factor-KDR/Flk-1 and PI3K-Akt-eNOS signaling pathways . Hong 2009

 

Panax notoginseng flower extract was found to attenuate lipopolysaccharide-induced inflammatory response in RAW264.7 murine macrophages by blocking the NF-kappaB signaling pathway. Jung 2009

 

Panax notoginseng saponins were found to dose-dependently significantly increase glucose uptake and glycogen synthesis in adipocytes, which may may have a therapeutic potential for hyperglycemia in type 2 diabetes. Kim 2009

 

Panax notoginseng aqueous extract was found to dose-dependently induce apoptosis in human lung carcinoma cells, an effect associated with Bcl-2 and caspase-3 expression, mitochondrial dysfunction, and dephosphorylation of the Akt signaling pathway. Park 2009

 

25-OCH(3)-PPD from Panax notoginseng decreased survival, inhibited proliferation, and induced apoptosis and G1 cell cycle arrest in three human lung cancer cell lines. No observable cytotoxicity was seen when administered to animals and demonstrated low toxicity to non-cancer cells. Wang 2009

 

Ginsenoside Rg1, an active saponin from Panax notoginseng, was shown to provide a protective effect against beta-secretase activity and ABeta-induced cytotoxicity in PC12 cells, which amay be beneficial in Alzheimer's disease. Wang 2009

 

Ginsenoside Rg1, an active saponin from Panax notoginseng, inhibited transforming growth factor-beta 1-induced tubular epithelial to myofibroblast transition in rat renal tubular epithelial cells via suppressing expression of P-ERK1/2. Xie 2009

 

Panax notoginseng extract was found to delay human umbilical endothelial cell replicative senescence by downregulating the expression of NADPH oxidase subunit-p47phox and decreasing oxidant generation. [Article in Chinese] Yang 2009

 

A polyherbal formulation including Panax notoginseng delayed aging of human umbilical vascular endothelial cells induced by angiotensin II , downregulating the expression of NADPH oxidase subunit-p47phox through AT1 R and reducing superoxide anion production. [Article in Chinese] Yang 2009

 

Panax notoginseng saponins enhanced phagocytosis in rat peritoneal macrophages by inhibiting cyclooxygenase-2 expression at an early stage and elevating it at a later stage. Yuan 2009

 

Buyang Huanwu decoction, as well as its alkaloids, glycosides, and total Panax notoginseng saponins, were found to inhibit vascular smooth muscle cell proliferation induced by platelet-derived growth factor similarly to atorvastatin. [Article in Chinese] Zhong 2009

 

Pretreatment with ginsenoside Rg1, an active saponin from Panax notoginseng, was shown to provide a dose-dependent protective effect against hypoxia/reoxygenation oxidative injury in rat cardiomyocytes partially due to antioxidant and intracellular calcium homeostasis. Zhu 2009

 

Panax notoginseng saponins exhibited antioxidant activity by scavenging hydroxide ions and protecting DNA chains from being damaged by the hydroxyl radical. [Article in Chinese] Gao 2008

 

Panaxydol, a non-peptidyl molecule isolated from Panax notoginseng, was found to dose-dependently inhibit the proliferation of C6 glioma cells via G0/G1 cell cycle arrest and induction of p27 expression and differentiation. Hai 2008

 

Panax notoginseng extract dose-dependently promoted cell proliferation, migration, DNA synthesis and vascular endotheial growth factor mRNA expression in human umbilical vascular endothelial cells. Lei 2008

 

Panax notoginseng root extract administered in a medicated serum was found to inhibit the proliferation and promote the apoptosis of precancerous gastric cells via modulating expressions of the bcl-2, Bax and p21WAF1 genes. Li 2008

 

Panax notoginseng was found to significantly attenuate TNFalpha-induced expression of adhesion molecule VCAM-1 and to inhibit DNA synthesis and cell growth in human vascular endothelial cells in vitro. Ling 2008

 

Panax notoginseng saponins exhibited a protective effect against ox-LDL-induced injury in human umbilical vascular endothelial cells by down-regulating the expression of intercellular adhesion molecule-1 and inhibiting the adherence of monocytes. [Article in Chinese] Qin 2008

 

Panax notoginseng attenuated production of inflammatory molecules and innate immune responsiveness of toll-like receptor ligand-induced activation of lipopolysaccharide-induced murine dendritic cells. Ginsenoside Rg1 more effectively inhibited LPS-stimulated cytokine production than ginsenoside Rb1. Rhule 2008

 

20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol (25-OCH3-PPD), isolated from Panax notoginseng, decreased survival, inhibited proliferation, induced apoptosis, and led to G1 cell cycle arrest in LNCaP and PC3 prostate cancer cell lines as well as xenograft models. Wang 2008

 

Nucleosides adenosine and guanosine and ginsenoside Rh1 and ginsenoside F1 were found to contribute to the anti-platelet aggregation activity of Panax notoginseng in human platelets. Wang 2008

 

Panax notoginseng saponins were found to inhibit ADP-induced platelet aggregation of rat washed platelets with the regulation of reactive oxygen species level possibly contributing to the effect. Yao 2008

 

Panax notoginseng saponins were found to upregulate glucocorticoid receptor nuclear transcription factor in hematopoietic cells and to promote human progenitor cells proliferation in CD34+ cells and bone marrow nuclear cells. Gao 2007

 

Panax notoginseng was found to up-regulate genes associated with hematopoietic cell proliferation and differentiation in cDNA microarray gene analysis. [Article in Chinese] Gao 2007

 

Panaxydol, a non-peptidyl small molecule isolated from the lipophilic fractions of Panax notoginseng, was found to dose-dependently reduce growth and induce apoptosis in rat C6 glioma cells, effects associated with decreased expression of bcl-2 and increased levels of Bax and caspase-3. Hai 2007

 

Panaxadiol glycoside Rg5 from Panax notoginseng dose- and time-dependently promoted neuronal differentiation in neurosphere stem cells at the expense of astrogliogenesis. The effect was reduced by the Ca2+ channel antagonist nifedipine. Liu 2007

 

An herbal formula including Panax notoginseng aqueous extract was found to inhibit the proliferation, differentiation, and apoptosis of hepatocarcinoma Bel-7402 cells, arresting cells in the S phase and exhibiting cytotoxic activity against the cells. Yan 2007

 

Panax notoginseng exhibited an anti-fibrosis effect on scar tissue by inhibiting transdifferentiation of cultured human fibroblasts. [Article in Chinese] Yao 2007

 

Panax notoginseng total saponins induced partial mononuclear cells in cord blood to differentiate into endothelial cells but did not exhibit synergistic activity with VEGF. [Article in Chinese] Zheng 2007

 

Panax notoginseng saponins exhibited a protective effect on human bone marrow hematopoietic cells, inhibiting the expression of Daxx and Fas proteins, increasing expression of NFkB and c-Rel proteins, increasing survival, and decreasing apoptosis. [Article in Chinese] Chen 2006

 

Ginsenoside-Rd, an active saponin from Panax notoginseng, was found to inhibit Ca2+ entry through receptor-operated and store-operated Ca2+ channels in vascular smooth muscle cells without affecting voltage dependent inward current and Ca2+ release. Guan 2006

 

Panax notoginseng was found to concentration-dependently inhibit lipopolysacchride-induced inflammatory activation of RAW264.7 macrophages by inhibiting NF-alpha and IL-6 and attenuating COX-2 and IL-1 beta expression. Rhule 2006

 

Panax notoginseng saponins were found to reduce leukocyte adhesion in rat mesentery venules by exhibiting an inhibitory effect against the expression of adhesion molecules CD11b and CD18 in neutrophils. Sun 2006

 

Panaxynol, isolated from Panax notoginseng, was found to induce differentiation of PC12D cells in a process similar to but distinct from that of NGF via cAMP- and MAP kinase-dependent mechanisms. Wang 2006

 

Panax notoginseng was found to significantly inhibit proliferation of vascular smooth muscle cells induced by hyperlipidemic serum. [Article in Chinese} Wang 2006

 

Ginsenoside Rg2 from cultured cells of Panax notoginseng was found to stimulate human umbilical cord vein endothelial cell proliferation and plasminogen activator expression. Xin 2006

 

Ginsenoside Rd from Panax notoginseng concentration- and time-dependently inhibited HeLa cell proliferation and induced apoptosis via down-regulating Bcl-2 expression, up-regulating Bax expression, lowering mitochondrial transmembrane potential, and activating the caspase-3 pathway. Yang 2006

 

Notoginsenoside R1, a saponin from Panax notoginseng, inhibited TNF-alpha-induced plasminogen activator-inhibitor mRNA overexpression in human aortic smooth muscle cells by suppressing ERK and PKB signaling pathways. Zhang 2006

 

Notoginsenoside R1 from Panax notoginseng inhibited TNF-alpha-induced ERK activation and subsequent fibronectin overexpression and migration in human arterial smooth muscle cells by suppressing NADPH oxidase-mediated ROS generation and directly scavenging ROS. Zhang 2006

 

The immunomodulatory effect of high molecular weight fractions of Panax notogiseng extract on the human complement system, polymorphonuclear neutrophils, and peripheral blood mononuclear cells was evaluated. Zhu 2006

 

Panax notoginseng significantly reduced angiotensin II-induced neonatal rat cardiomyocyte apoptosis via alleviating intracellular calcium overload. [Article in Chinese] Chen 2005

 

Trilinolein, isolated from Panax notoginseng, was found to inhibit endothelin-1-induced beta-myosin heavy chain promoter activity and subsequent hypertrophy in neonatal rat cardiomyocytes via antioxidant activity. Chen 2005

Panaxynol, an active component of Panax notoginseng root extract, was found to upregulate M1 muscarinic acetylcholine receptors in transfected CHO cells through significant and consistent cAMP pathway-mediated stimulation of gene transcription. Hao 2005

 

Panax notoginseng extract was found in vitro to decrease the number of precancerous cells in the G(0)/G(1) phase and to increase the number of the cells in G(2)/M phase. [Article in Chinese] Li 2005

 

Panax notoginseng saponins (PNS) and ginsenoside-Rd promoted the differentiation of neurospheres into astrocytes, while ginsenoside-Rd increased production of astrocytes; both PNS and ginsenoside-Rd induced a weak but significant effect by decreasing the number of neurons. Shi 2005

 

Apoptosis of rat hepatic stellate cells induced by Panax notoginseng saponins. [No abstract] [Article in Chinese] Wang 2005

 

Trilinolein from Panax notoginseng inhibited endothelin-1-induced extracellular signal-regulated kinase phosphorylation, c-Jun NH2-terminal kinase phosphorylation, and c-fos gene expression in rat neonatal cardiomyocytes via attenuating superoxide production. Yang 2005

 

Panax notoginseng was found to significantly promote transformation of bone marrow stem cells and proliferation of endothelial progenitor cells collected from marrow blood of patients with ischemia of the lower limbs. [Article in Chinese] Yang 2005

 

Panax notoginseng saponins was found to time-dependently reduce procoagulant activity and TF-mRNA expression, as well as to partially induce differentiation, in NB4 cells. [Article in Chinese] Li 2004

 

Trilinolein, isolated from Panax notoginseng root, inhibited angiotensin II-induced hypertrophy and beta-myosin heavy chain promoter activity via antioxidant activity in cultured neonatal rat cardiomyocytes. Liu 2004

 

Trilinolein, an active component of Panax notoginseng, exhibited an inhibitory effect against norepinephrine-induced beta-myosin heavy chain promoter activity, reactive oxygen species generation, and extracellular signal-regulated kinase phosphorylation in neonatal rat cardiomyocytes. Liu 2004

 

In an evaluation of the antioxidant capacity of aqueous and methanolic Panax notoginseng extracts, P. notoginseng was shown to have weaker potencies than P. quinquefolium, Glehnia littoralis, Codonopsis pilosula, and Pseudostellaria heterophylla. Ng 2004

 

Panax notoginseng saponins were found to upregulate the activity of human endothelial nitric oxide synthase gene promoter transfected into NIH3T3 cells. [Article in Chinese] Zhang 2004

 

Panax notoginseng saponins were found to exhibis an inhibitory effect against hypoxia/hypoglycemia- and reoxygenation-induced neuronal apoptosis in cultured rat hippocampal neurons, possibly by decreasing intracellular free calcium concentration. [Article in Chinese] Zhu 2003

 

Ginsenoside Rg1, a saponin from Panax notoginseng, exhibits dose-dependent estrogen-like activity in estrogen receptor-positive MCF-7 breast cancer cells via stimulation of [methyl-(3)H] thymidine incorporation; the activity is not mediated via the estrogen alpha receptor. Chan 2002

 

Panax notoginseng extract was found to increase neurite outgrowth in SK-N-SH cells, while the percentage of cells with multipolar neurites and number of varicosities were intensely high in cells treated with ginsenosides Rb and Rb and notoginsenosides R and Fa. Tohda 2002

 

Panax notoginseng saponins were found to concentration-dependently inhibit the proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblasts. [Article in Chinese] Wei 2002

 

Ginsenoside Rc from Panax notoginseng flowers significantly enhanced human sperm motility and progression at the end of the 1st and 2nd hour, while ginsenoside Rb2 did not increase sperm motility at the 1st or 2nd hour but promoted sperm progression at the 2nd hour. Chen 2001

 

Panax notoginseng saponins exhibited a protective effect against ischemic reperfusion injury in hepatocytes in the early stages of intrasplenic hepatocellular autotransplantation. Deng 2001

 

Rg1, a purified saponin from Panax notoginseng, was shown not to a Ca2+ channel antagonist in guinea pig ventricular myocytes. [Article in Chinese] Zhang 1999

 

Panax notoginseng saponins were found to increase motility as well as progression of human sperm. Chen 1998

 

Notoginsenoside R1, a saponin from Panax notoginseng, was found to dose-dependently increase the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery by increasing production of t-PA and u-PA. Zhang 1997

 

Panax notoginseng polysaccharides were shown to exhibit anticomplementary and immunostimulating activities in human serum and antibody-sensitized sheep red blood cells and in isolated mouse spleen lymphocytes and peritoneal macrophages, Gao 1996

 

Panax notoginseng saponins provided protection against hypoxic neural damage in cultured neurons of the chick embryo cerebral hemisphere, an effect associated with improving energy metabolism and preserving structural integrity of neuronal cells. Jiang 1995

 

Panax notoginseng saponins inhibited total myocardial ATPase, but had no significant effect on myocardial Na(+)-K(+)-exchanging ATPase in isolated guinea pig heart; Rg1 and Rb1 inhibited total myocardial ATPase while Rb1 also inhibited automaticity and contractility of atria. Chen 1994

 

Panax notoginseng saponin fraction R1 was found to dose- and time-dependently increase synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. Zhang 1994

 

Panaxadiol saponins were found to inhibit release of intracellular Ca2+ and block inflow of extracellular Ca2+ in isolated guinea pig colon. [Article in Chinese] Dan 1993

 

Panax notoginseng saponins inhibited the proliferation of aortic smooth muscle cells stimulated by hypercholesterolemic serum, which may be beneficial in prevention of atherosclerosis and inhibition of progression of atherosclerotic lesions. Lin 1993

 

Panax notoginseng extract was shown to activate rat brain synaptosomal Na(+)-K(+)-ATPase, leading to a reduced Na+/Ca2+ exchange, a lowered intracellular Ca2+ level, and reduced heart contractility. Jin 1991

 

Panax notoginseng saponins decreased the duration of fast action potential, shortened contractile force, and depressed maximal upstroke velocity and amplitude of slow action potential in cultured myocardial cells of neonatal rat via inhibition of Ca2+ influx signalling. [Article in Chinese] Li 1990

 

Studies on anti-arrhythmia effects of panaxatriol saponins isolated from Panax notoginseng. [No abstract] [Article in Chinese] Li 1988

 

Depressant actions of Panax notoginseng saponins on vascular smooth muscles. [No abstract] [Article in Chinese] Wu 1988

 

Negative chronotropic and inotropic effects of Panax notoginseng saponins. [No abstract] [Article in Chinese] Wu 1988

 

Pharmacological studies on notoginseng saponins isolated from the fibrous root of Panax notoginseng. [No abstract] [Article in Chinese] Chen 1987

 

Anti-inflammatory effects of total saponins of Panax notoginseng. [No abstract] [Article in Chinese] Zhongguo 1986

 

Analgesic and central nervous system inhibiting effects of total saponins extracted from the leaves of Panax notoginseng. [No abstract] [Article in Chinese] Lei 1984

 

Anti-arrhythmic effect of total saponins of Panax notoginseng. [No abstract] [Article in Chinese] Liu 1984