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Observational Studies/Case Reports

June 08, 2020

Observational Studies/Case Reports from PubMed.gov

In 2 studies with 6 subjects, (3 males, 3 females), a single dose of 2500 mg commercial Panax notoginseng extract in water Panax notoginseng was shown to provide a mild genoprotective effect against H2O2-induced DNA damage in lymphocytes, enhancing resistance to oxidative damage. Szeto 2014

Based upon a retrospective analysis (n=35), combining conventional treatment with Panax notoginseng administration was found to be an efficient method in improving clinical symptoms of multiple fractured ribs and pulmonary contusions. Tianhong 2014

Panax notoginseng for 3 days in combination with acute exercise was shown to lower postprandial glycemia in non-diabetic adults. Liang 2012

In 2 cases in which patients with pancreatic adenocarcinoma and mucosa-associated lymphatic tissue type lymphoma, respectively, were treated with Panax notoginseng and Cordyceps militaris herbal formulas, reduction in tumor mass in both patients after 17 and 13 months of treatments was noted. Yoo 2011

In a randomized controlled study (n=60), administration of Panax notoginseng for 2 months was shown to exhibit a therapeutic effect in non-uremic chronic renal failure patients, including improving renal function and lowering urine protein excretion. [Article in Chinese] Peng 2010

In a 3-week, randomized,controlled study with patients (n=50) whose disease was not more than 5 days, Panax notoginseng along with conventional treatment provided a protective effect against cerebral hemmorhage by protecting neurons and promoting functional rehabilitation. [Article in Chinese] Wei 2007

Ginsenoside -2A, an active saponin purified from Panax notoginseng, exhibited antiplatelet activity in hypertense and normal patient platelet rich plasma prepared from venous blood samples. [Article in Chinese] Nie 2006

In a randomized study, administration of Panax notoginseng saponins and astragalus provided a protective effect against diabetic macroangiopathy in patients with type-2 diabetes, improving serum levels of MMP-9, TG, TC, LDL-C, VLDL-C, and HDL-C. [Article in Chinese] Liu 2004

Panax notoginseng saponins, alone and in combination with isovolumic haemodilution, improved retinal microcirculation and promoted absorption of retinal hemorrhage, edema, leakage of capillary, and cystoid macular edema in patients with retinal vein occlusion. [Article in Chinese] Xi 2000

Incubation with Panax notoginseng aqueous extract, n-butanol extract, and a polysaccharide fraction enhanced motility and progression of inferior human sperm in vitro. Chen 1999

Panax notoginseng restored normal T/K ratio, improved dmicrocirculation, reduced whole blood viscosity, and decreased urinary albumin in early diabetic nephropathy patients. [Article in Chinese] Lang 1998

Panax notoginseng saponins improved myocardial relaxation function in patients with essential hypertension via enhancing calcium pump activity, inhibiting intracellular calcium overload, and lightening left ventricular muscle mass. [Article in Chinese] Feng 1997

116 cases of coronary angina pectoris were treated with a traditional Chinese formulation including Panax notoginseng. Results indicated efficacy better than control group, including improvements in ECG, general symptoms, physical strength, lipid metabolism, and microcirculation of nail fold. Yuan 1997