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Modern Methods of Preparation

June 08, 2020

Modern Methods of Preparation by pubmed.gov

Panax notoginseng saponin microspheres prepared by a double emulsion method using a series of degradable amphiphilic macromolecule materials polyethylene glycol monomethyl ether-polymandelic acid were found to be released stably for ~12 days and degraded within 60 days. He 2019

 

The formulation of ginsenoside Rbi, a saponin from Panax notoginseng, in a chitosan and alginate noncomposite film was optimized for slow release via oral administration. Hoang 2019

 

Panax notoginseng saponin fraction was shown to be an alternative stabilizer for preparation of breviscapine nanocrystals, as well as to enhance the bioavailability and synergistic antiplatelet aggregation effect of breviscapine. Jin 2019

 

An acid hydrolyzing chemical transformation was developed to acquire the rare notoginsenoside Ft1 from Panax notoginseng extract, resulting in a preparation yield rate of about 1.8%. Wang 2018

 

Application of jasmonic acid and methyl dihydrojasmonate was found to enhance saponin biosynthesis as well as expression of functional genes in the adventitious roots of Panax notoginseng. Li 2017

 

Molecularly imprinted polymers for solid phase extraction of dencichine, an active component of Panax notoginseng, were developed using bulk polymerization of phenylpyruvic acid and dl-tyrosine as multi-templates. Ji 2016

 

Panax notoginseng nanoemulsion developed using a pseudoternary phase diagram and prepared by high pressure homogenization was shown to increase bioavaliability in a pharmacokinetic study of rat intestinal absorption. Liu 2016

 

Panax notoginseng saponins/tanshinone II(A) composite particles were prepared with spray-drying and characterized for pulmonary delivery. The dry powder particles were found to have narrow particle size distribution range and good aerodynamic behavior. [Article in Chinese] Wang 2013

 

Conditions used in the spray-drying process on physical and chemical properties and lung inhaling performance of Panax notoginseng saponins/tanshinone II A composite particles were evaluated with results indicating ethanol-acetone (9: 1) and 110 degrees C to be most effective. [Article in Chinese] Wang 2013

 

Steaming was found to change the chemical profile and anti-cancer activities of Panax notoginseng, with steamed P. notoginseng exhibiting greater anti-proliferative effects against liver cancer cells than raw P. notoginseng and increasing concentrations of ginsenosidse Rh2, Rk1, Rk3 and 20S-Rg3. Toh 2011

 

The influence of HPMC (K4M, K15M, K100M) and Carbomer (934P, 971P, 974P) was evaluated for the release kinetics of ginsenoside-Rg1, ginsenoside-Rb1, and notoginsenoside-R1 from Panax notoginseng in simulated gastric fluid. [Artilce in Chinese] Zhou 2010

 

Transmissivity of active saponins from Panax notoginseng extract was compared using four different membrane parameters (such as pore diameter of membrane, operational pressure, temperature, and concentration of liquid) by orthogonal test. [Article in Chinese] Xiong 2009

 

The addition of phenobarbital to cell suspension culture of Panax notoginseng increased production of protopanaxatriol-type (Rg(1) + Re) ginsenosides in both shake flask and airlift bioreactors. Yue 2008

 

Jasmonic acid was effectively applied as a signal transducer to alter levels of ginsenoside heterogeneity in Panax notoginseng cell culture. Hu 2007

 

The optimal pH of Panax notoginseng compound decoctions and other Chinese herbs was evaluated using notoginsenoside R1, Rg1, Re, and Rb1 as markers. [Article in Chinese] Huang 2007

 

The extraction and filtration rate of Panax notoginseng saponins Rg1, Re, Rb1, and notoginseng saponin R1 were determined by alcoholic and aqueous extraction in tablet, coarse powder, ultra-fine powder and reconstitution granules of ultra-fine powder forms. [Article in Chinese] Huang 2005

 

Somatic embryogenesis was induced in callus tissues derived from young flower buds of Panax notoginseng via callus within 18 weeks of culture for clonal micropropagation. Shoyama 1997