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Literature Reviews

June 08, 2020

 Literature Reviews

Notoginsengoside R-1 in metabolism and biological activities, including cardiovascular protection, neuroprotection, antidiabetes, liver protection, gastrointestinal protection, lung protection, bone metabolism regulation, renal protection, and anticancer, are discussed. Liu 2020


The pharmacological activities of panaxadiol and protopanaxadiol, the active saponins from Panax notoginseng, are comprehensively summarized in this review. Wang 2020


This review presents information on Tongluojiunao, a traditional Chinese formulation including Panax notoginseng root, on central nervous system conditions, including cellular and molecular targets, inflammatory responses, neurogenesis and angiogenesis mediators, and cognitive function. Bibak 2019


Anticancer effects of Panax notoginseng and ginsenoside isolates against breast cancer are reviewed, focusing on mechanisms of action such as modulation of cell growth, cell cycle, and cell death; inhibition of angiogenesis, metastasis, and multidrug resistance; and cancer immunemodulation. Guo 2019


A review of notoginsenoside R1, an active saponin isolated from Panax notoginseng, for its pharmacological properties based upon in vitro and in vivo studies reports neuroprotective, anti-inflammatory, anti-apoptosis, and anti-ischemia-reperfusion injury properties, among others. Guo 2019


This review discusses the antimicrobial activities of Panax notoginseng and compares the activity to other members of the Panax genus. Wang 2019


This review summarizes the analytic approaches used for the identification and quantitation of Panax notoginseng saponins, as well as their biological effects developed in the last decade. Xu 2019


This review of the pharmacological effects and mechanisms of action of ginsenoside Rb1 from Panax notoginseng in the management of diabetes or diabetic complications, concludes it exerts significant anti-obesity, anti-hyperglycemic, and anti-diabetic effects. Zhou 2019


This review summarizes and compares the proteins present in Panax notoginseng with those from other Panax species and evaluates the distinguishing structural features and bioactivity. Chan 2018


The current review provides a comprehensive overview of chemical compositions of raw and processed Panax notoginseng with a particular emphasis on saponin stereoisomers. Pharmacological research and preparation methods of stereoisomeric saponins are also discussed. Peng 2018


This paper provides an overview of ancient and traditional methods of preparing Sanqui, or Panax notoginseng, for use in Chinese Traditional Medicine, and includes a comparison with modern processing methods. [Article in Chinese]. Wu 2018


This review summarizes the pharmacological effects and the four dominant mechanisms underlying the activity ginsenoside Rg1, a saponin from Panax notoginseng, used in treatment of cerebral ischemia and reperfusion injury. Xie 2018


This review identified the inflammatory pathway as the key signaling pathway for determining efficacy of Panax notoginseng in the treatment of chronic diseases, including inflammatory bowel disease, arthritis, ischemia, atherosclerosis, Alzheimer disease, hyperlipidemia, diabetes, and others. Xu 2018


This review summarizes the chemical components, pharmacological actions, including antihypertensive, anticancer, hepatoprotective, and cardiovascular protective effects, and clinical uses of Panax notoginseng flower buds. Zhang 2018


Research on the anticancer activity of steamed Panax notoginseng is evaluated and compared to non-steamed Panax notogiseng and other steamed Panax species. Wang 2016


In this review, the phytochemistry and analysis of anticancer compounds from Panax notoginseng are presented and compared with other Panax species. Wang 2016


This review provides up-to-date information on Panax notoginseng, including botany, ethnopharmacology, phytochemistry, pharmacology, and toxicology of the plant and its active compounds, as well as possible applications and perspectives for future investigation. Wang 2016


This review presents data on the pharmaceutical actions and molecular mechanisms of Panax notoginseng and its saponins for ischemia-reperfusion injury. [Article in Chinese] Yang 2016


This review highlights recent findings on the chemistry and bioactivities of tetracyclic triterpenoids from Panax notoginseng and other popular herbal medicines. Hamid 2015


The present review summarizes the saponins isolated from Panax notoginseng and their distribution in different plant parts, as well as the pharmacological actions on the cardiovascular system. [Article in Chinese] Li 2015


A summary of the phytochemical and analytical studies of aerial parts of several Panax species, including Panax notoginseng, is presented to provide evidence for further investigation of chemical profile, quality control, and optimal utilization of the plants. [Article in Chinese] Bai 2014


This reveiw found that over the past 10 years China has maintained its interest in Panax notoginseng research and its neuroprotective role in ischemic brain injury but that there are no large-scale clinical data to confirm its efficacy and safety. Li 2014


A summary and appraisal of the latest literature on Panax notoginseng saponins (PNS) as therapeutic agents against cardiovascular diseases is presented; major PNS structures are introduced, cellular targets and signaling pathways are analyzed, and clinical applications are . Liu 2014


This review summarizes the Traditional Chinese Medicines available to promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells, including Panax notoginseng. Si 2014


The pharmacological mechanisms of Panax notoginseng saponins (including protoparaxotriol saponins, panasadiol saponins, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, and notoginsenoside R1) on nervous system diseases are summarized. [Article in Chinese] Su 2014


The present review highlights the effects of Panax notoginseng saponins on glucose production and absorption, and on inflammatory processes that play an important role in the development of diabetes. Uzayisenga 2014


This comprehensive review describes advances in the phytochemistry and the investigational history of the genus Panax, including Panax notoginseng, from 1963-2012 with references from 134 papers. Yang 2014


A review of 10 moderate-to-low quality randomized controlled trials (n-969) showed Panax notoginseng saponin injection alone to be no different than conventional drugs in improving symptoms of angina pectoris; however, co-treatment was shown to be a better option than conventional drugs alone. Yang 2014


A review of the pharmacology of the monomers Rb1, Rg1, and R1, all bioactive saponins from Panax notoginseng, in the treatment of cardiovascular diseases is presented. Yang 2014


The chemical diversity of Panax notoginseng, P. ginseng, and P. quinquifolium is discussed, noting that they contain saponins which can be classified as dammarane-type, ocotillol-type, and oleanane-type oligoglycosides, and polysaccharides as main constituents. Kim 2012


This review summarizes the potential of Panax notoginseng in the treatment of the keloid scars, noting that studies have shown ginseng inhibits NF-kappa B, TGF-β, IL-6, ACE, and MMP-2 which play a pivotal role in keloid formation pathogenesis. Pazyar 2012


This review summarizes some important experimental findings regarding the mechanisms of action of certain herbal medicines, including Panax notoginseng, against atherosclerosis. Zeng 2012


This review reports on extracts from 37 medicinal plant species, including Panax notoginseng, which have been shown to modulate either gene or protein activity of cell adhesion molecules. Spelman 2011


This review describes the past and present preclinical and clinical bioactivity, formulations, pharmacokinetics, and safety of 107 chemical entities separated from the roots, leaves, and flower buds of Panax notoginseng and other Panax species. Jia 2009


This review, which discusses traditional medicine in the treatment of drug addiction, found that Panax notoginseng lacked evidence to be considered a viable treatment option for alcohol addiction. Lu 2009


This review discusses plant-derived saponins as new adjuvant candidates from traditional Chinese medicinal herbs such as Panax notoginseng. Song 2009


Potential roles of ginseng herbs, especially Panax notoginseng, in colorectal cancer therapeutics are reviewed, along with structure-activity relationship between chemical structures and pharmacological activities and effects of heat treatment on efficacy. Wang 2008


This review discusses recent clinical and experimental studies on the treatment of intracerebral hemorrhage with active ingredients of Panax notoginseng, including therapeutic mechanisms, acting pathways, and clinical effect. [Article in Chinese] Hu 2006


This review discusses pharmacology, constituents, disease models, and quality control of Panax notoginseng, including actions against cerebral ischemia' effects on cardiovascular system; and haemostatic, antioxidant, hypolipidemic, hepatoprotective, renoprotective and estrogen-like activities. Ng 2006


Phamacological effects of trilinolein, a triacylglycerol isolated from Panax notoginseng, are reviewed, including reducing thrombogenicity and arrhythmias, increasing erythrocyte deformability. and antioxidant activity. Chan 2002


A review of adverse effects of Panax notoginseng. [No abstract] [Article in Chinese] Yang 2002


Progress in the study on protective effect of saponins Panax notoginseng on ischemic brain damage. [No abstract] [Article in Chinese] Han 1996


The antihypertensive activity of the active saponins extracted from Panax notoginseng on smooth muscle cells is reviewed. Kwan 1995


This review discusses the immunomodulatory traditional Chinese herbs, including Panax notoginseng, focusing on mechanisms of action. Li 1991