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June 08, 2020

Panax notoginseng saponins exhibited a protective effect against cisplatin-induced mitochondrial damage in rats via reducing levels of ROS, malondialdehyde, and nitric oxide, as well as the opening of the mitochondrial permeability transition pore. Li 2020

Panax notoginseng and Astragalus membranaceus exhibited synergistic activity in ameliorating podocyte injury in streptozotocin-induced diabetic mice. partly via upregulation of nephrin, α-dystroglycan, and Bcl-xl, and downregulation of Bax and Nox4. Zhai 2019

Panax notoginseng saponins exhibited a concentration-dependent inhibitory effect on aspirin hydrolysis in Caco-2 cell monolayers, while an insignificant effect was observed on the mRNA expression of esterases. Sun 2018

Astragalus extract and Panax notoginseng saponins exhibited a synergistic protective effect against cerebral ischemia-reperfusion induced brain damage in mice, possibly by improving early energy metabolism and relieving delayed apoptosis via JNK signal transduction. Huang 2017

Panax notoginseng and Bletilla striata, containing two ginseng saponins (20S)-ginseng saponin Rg₃ and ginseng saponin Rh₄, exhibited significant synergistic inhibitory activity against lipase. [Article in Chinese] Liu 2016

Notoginsenoside R1, a saponin from Panax notoginseng, exhibited an inhibitory effect on CYP1A2, but had no effect on CYP2C11, CYP2D1, and CYP3A1/2 rat liver enzymes. Yin 2016

The plasma concentrations and distribution characteristics of nine endogenous hepatotoxic metabolites from Tripterygium wilfordii were reduced after oral administration of the aqueous extract of Panax notoginseng in rats. Zhang 2016

The combination of notoginsenoside Rg1 and salvianolic acid B, but not the combination of Rb1 salvianolic acid B, improved heart contractility in rats with ligation-induced myocardial infarction. Deng 2015

Astragaloside IV and Panax notoginseng saponins exhibited synergistic protection against cerebral ischemia injury in mice via anti-apoptosis and anti-inflammatory activity, effects associated with reducing NF-κB and JAK1/STAT1 signal pathways and regulating endoplasmic reticulum stress. Huang 2015

Astragaloside IV and Panax notoginseng saponins exhibited synergistic activity in improving energy metabolism in the brain of cerebral ischemia-reperfusion mice, possibly by promoting activation of AMPKα1/2, enhancing expression of GLUT3, and mediating glucose into nerve cells. Huang 2015

20(S)-protopanaxadiol-type ginsenosides were found to be potent inhibitors of OATP1B3, which may induce hepatobiliary herb-drug interactions, particularly when patients receive long-term therapies with high-dose i.v. Panax notoginseng roots (Sanqi). Jiang 2015

Panax notoginseng saponins induced CYP1A2 and CYP2E1 enzyme activity, mRNA expression, and CYP2E1 protein expression, as well induced CYP3A mRNA expression in rats; no significant effect was found in CYP3A enzyme activity or CYP1A1 and CYP2B mRNA expression and enzyme activity. [Article in Chinese] Chen 2014

Panax notoginseng saponins exhibited a dose-dependent protective effect against hypoxia and reoxygenation injury in cardiomyocytes by inhibiting apoptosis and improving energy metabolism; a synergistic effects was seen with salvianolic acids. [Article in Chinese] Gong 2013

Ginsenoside Rg1 and notoginsenoside R1 from Panax notoginseng were found to be the active compounds responsible enhancing the cytotoxic action of cisplatin in the presence of functional gap junctions. Zhang 2013

In a double-blind, randomized, controlled trial (n=140), aspirin in combination with a traditional Chinese medicine containing Panax notoginseng root was effective at improving outcomes in patients of ischemic stroke in anterior cerebral circulation within 30 days of onset. He 2011

Administration by gavage for 4 days of Panax notoginsenoside in combination with astragaloside exhibited a dose-dependent synergistic effect against early oxidative stress injury in the brain in ischemia-reperfusion mice. [Article in Chinese] Tan 2010

Co-administration of Panax notoginseng saponins and Cornus officinalis saponins exhibited some effect on improving myocardial ischemia in mice, as well as and a role in anti-anoxia. [Article in Chinese] Tang 2010

Panax notoginseng saponins did not exhibit an obvious effect on testotesrone metabolism in rat liver microsomes and did not interact with CYP3A4 liver enzyme. [Article in Chinese] Shen 2009

Oral administration of Panax notoginseng for 14 days exhibited inhibitory selectivity on the expression of CYP2B1 and CYP4A1 genes in liver tissues of rats but not CYP1A1, CYP1A2, CYP2E1, and CYP3A1 expression. [Article in Chinese] Yang 2009

Panax notoginseng (PNS) exhibited a protective effect against doxorubicin-induced cardiotoxicity in ICR mice; in vitro cytotoxic studies demonstrated that PNS did not compromise the inhibitory effect of doxorubicin on the proliferation of cancer cells. Liu 2008

Administration of Panax notoginseng gel in combination with ultrasonic phonophoresis was shown to improve post-surgical ligament repair in rats, significantly normalizing stiffness and ultimate tensile strength; an insignificant difference in load-relaxation was seen. Ng 2008

Both salvianolic acids and notoginsengnosides exhibited an inhibitory effect on platelet aggregation in vitro with no synergistic effect seen when combined; however, when combined at a ratio of 5:1, a synergistic effect on platelet aggregation of platelet rich plasma was seen in rats. Yao 2008

Icariin combined with Panax notoginseng saponins exhibited a protective effect against bilateral common carotid artery occlusion-induced cerebral ischemia-reperfusion injury in rats, possibly ameliorating learning and memory deficit and blood viscosity by protecting neurons from oxidative stress. Zheng 2008

Panax notoginseng saponins attenuated doxorubicin-induced myocardial damage without affecting the drug's anti-tumor activity against H9C2 cells in mice. [Article in Chinese] Shi 2007

Panax notoginseng flower extract was shown to enhance the anti-proliferative effect of 5-fluorouracil against HCT-116 human colorectal cancer cells. Wang 2007

Panax notoginseng root extract, as well as notoginsenoside R1 ginsenosides Rg1, and Rb1, induced apoptosis in human colorectal cancer cells; the extract also enhanced the activity of two chemotherapy agents, 5-fluorouracil and irinotecan. Wang 2007

In a randomized study (n=120), combination treatment with a traditional Chinese formula containing Panax notoginseng and alprostadil injections for 14 consecutive days provided and enhanced effect in patients with early- and intermediate-stage diabetic nephropathy. [Article in Chinese] Zhao 2007

Fourier transform infrared spectroscopy showed Panax notoginseng saponins to combine with human serum albumin through C=O and C-N groups of the polypeptide chain and the combination to cause significant loss of alpha-helix structure and microenvironment changes in tyrosine residues. Liu 2003