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Animal Studies

June 08, 2020

Animal Studies by Pubmed.gov 

Panax notoginseng saponins regulated tumor-induced granule-monocyte differentiation of hematopoietic stem cells in tumor-bearing mice by changing the distribution and function of hemocytes. Guo 2020

 

Oral pre-administraton for two weeks of Panax notoginseng, in combination with Salvia miltiorrhiza, dose-dependently regulated serum lipidomics and amino acid profiles of rats with acute myocardial ischemia. Tao 2020

 

PNPS-0.5 M, a novel polysaccharide from the residue of Panax notoginseng, exhibited a hepatoprotective effect against alcohol-induced liver damage in mice. Wang 2020

 

Oral administration for 12 weeks of Panax notoginseng ameliorated albuminuria and podocyte epithelial-mesenchymal transition in streptozotocin-induced diabetic rats partly via inhibiting Wnt/β-catenin signaling pathway. Xie 2020

 

Steamed Panax notoginseng attenuated cyclophosphamide and acetylphenylhydrazine-induced anemia in mice via regulating hematopoietic factors and the JAK-STAT pathway. Zhang 2020

 

Intraperitoneal administration of Panax notoginseng saponins for 6 weeks reduced blood glucose and serum insulin levels and improved glucose tolerance and insulin tolerance in diabetic mice by regulating the IRS1-PI3K-AKT signaling pathway and glucose transporter type 4 expression. Guo 2019

 

Dencichine, the main renoprotective compound in Panax notoginseng against, reduced deposition of extracellular matrix in glomeruli and inhibited epithelial mesenchymal transformation STZ-induced diabetic nephropathy rats via inhibition of the TGF-β1/Smad signalling pathway. Li 2019

 

Pretreatment with Panax notoginseng saponins provided a protective effect against myocardial ischemia-reperfusion injury in rats mainly via enhancement of mitochondrial autophagy of myocardial tissue through the HIF-1α/BNIP3 pathway. Liu 2019

 

Notoginsenoside Ft1, a saponin fraction from Panax notoginseng, exhibited haemostatic activity in mice, an effect associated with potentiation of the phospholipase Cγ2-IP3 /DAG-[Ca2+ ]/PKC-TXA2 signalling pathway. Liu 201

 

Intragastric administration for 4 weeks of ginsenoside Rg1, a saponin from Panax notoginseng, provided a protective effect against Aβ1-42 injection-induced Alzheimer's disease cognitive impairment in rats via modulation of hyperphosphorylated β-amyloid precursor protein processing. Liu 2019

 

Administration by gavage for eight weeks of Panax notoginseng saponins and 20(S)-protopanaxadiol saponins, but not 20(S)-protopanaxatriol saponins, decreased atherosclerotic lesions in the ApoE-deficient mice aorta. Liu 2019

 

A polyherbal TCM formula including Salvia miltiorrhiza and Panax notoginseng was shown to regulate interstitial fibrosis, prevente ligation-induced myocardial infarct border zone remodelling, and reduce susceptibility to ventricular arrhythmias in post-myocardial infarction rats. Ma 2019

 

Panax notoginseng saponins were shown to promote cutaneous wound healing and suppress scar formation in mice, significantly expedited wound healing by reducing lesion size and suppressing scar formation, by inhibiting fibroblast accumulation and promoting NO production and NO synthase. Men 2019

 

Panax notoginseng saponins alleviated leukocyte adhesion, inhibited endothelial barrier alterations, ameliorated infarct volumes and neurological deficits, and ultimately reduced cerebral microvasculature barrier dysfunction in ischemia-reperfusion mice. Wu 2019

 

Rk3 and 20(S)-Rg3 saponin fractions from Panax notoginseng were shown to significantly increase levels of blood routine parameters, mitochondrial ferrochelatase, and its downstream protein of heme in mice with blood deficiency syndrome. Xiong 2019

 

Total Panax notoginseng saponins dose-dependently inhibited balloon injury-induced neointimal hyperplasia in rat carotid artery models via suppressing pERK/p38 MAPK pathways. Yang 2019

 

Notoginsenoside R1, a saponin from Panax notoginseng, exhibited a renoprotective effect against diabetic nephropathy in db/db mice via upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression. Zhang 2019

 

Panax notoginseng saponins reduced inflammatory response and oxidative stress in activated Kupffer cells, inhibiting NF-κB and Keap1-Nrf2-ARE pathways, promoting polarization of cells into M2 phenotype, and prolonging survival time of rats after liver transplantation. [Article in Chinese]. Zhang 2019

 

Panax notoginseng saponins were shown to reduce polymyxin E-induced nephrotoxicity in mice via inhibition of oxidative stress and prevention of cell apoptosis via the mitochondrial pathway. Zhang 2019

 

Panax notoginseng saponins were shown to promote liver regeneration after partial hepatectomy in mice through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway. Zhong 2019

 

Oral administration of notoginsenoside R1 from Panax notoginseng exhibited a protective effect against diabetic retinopathy in db/db mice, attenuating retinal vascular degeneration, reduced retinal thickness, and impaired retinal function, via PINK1-dependent enhancement of mitophagy. Zhou 2019

 

Oral administration of Panax notoginseng flower extract enhanced capillary density; decreased infarct size; improved minimal vessels; suppressed cell apoptosis; and enhanced expressions of HIF-1, VEGFA, and KDR genes and Bcl-2 and Bax proteins in myocardial infarction rats. Zhou 2019

 

Panax notoginseng saponins significantly ameliorated amyloid beta-induced Alzheimer's disease symptoms and resulting paralysis in C. elegans worms, effects associated with antioxidant activities and activated expression of SKN-1 mRNA, which further supports SKN-1 signaling pathway. Zhou 2019

 

Treatment with Panax notoginseng saponins was shown to upregulate five circular RNAs and downregulate two circular RNAs associated with Alzheimer's disease pathogenesis in mice. Huang 2018

 

A Panax notoginseng root and Rehmanniae Radix Preparata combination extract exhibited an antinociceptive and cartilage protective effect against monosodium iodoacetate induced-osteoarthritis in rats by suppressing oxidative injury, inflammatory mediators, and inducing anabolic factors. Jhun 2018

 

Aqueous extract of Panax notoginseng roots reduced both tumor weight and volume in an in vivo tumor allograft model by activating macrophages toward an M1 phenotype. Kim 2018

 

Panax notoginseng saponins combined with safflower flavonoids exhibited a dose-dependent cardioprotective effect against isoproterenol induced-myocardial infarction in rats by attenuating the NF-κB signaling pathway and reducing the expressions of TNF-α, IL-6, IL-1β, and PLA2. Meng 2018

 

A Chinese formulation of Panax notoginseng exhibited protective effects against diabetic retinopathy in streptozotocin-induced diabetic rats via reducing RAGE accumulation, decreasing inflammation, inhibiting renal fibrosis, and blocking the TGF-β/Smad2/3 signaling pathway. Wang 2018

 

Administration of notoginsenoside R1 for 10 weeks ameliorated cognitive dysfunction, depression-like behaviors, insulin resistance, hyperinsulinemia, dyslipidemia, and inflammation in mice, effects associated with activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome. Zhai 2018

 

Total leaf saponins of Panax notoginseng were shown to exhibit an antidepressant effect in chronic unpredictable mild stress mice, possibly by regulating the expression of a large number of circular RNAs. Zhang 2018

 

Panax notoginseng saponins protected alloxan-induced diabetic rats from diabetic retinopathy, possibly by up-regulating SIRT1 and thereby inhibiting inflammation via decreasing the induction of inflammatory cytokines and TGF-β1, as well as activating antioxidant proteins. Du 2016

 

Notoginsenoside R1, an active saponin from Panax notoginseng, exhibited a cardioprotective effect against ischemia-reperfusion-induced myocardial injury in rabbits, possibly by inhibiting activation of the TGF-β1-TAK1 signaling pathway and attenuating apoptotic stress in the myocardium. Ge 2016

 

Panax notoginseng polysaccharides were found to inhibit growth of H22 liver cancer cells and significantly prolong survival of tumor-bearing mice, effects associated with activating CD4(+) T-cells and elevating serum interleukin-2. Li 2016

 

Panax notoginseng saponins exhibited a neuroprotective effect against middle cerebral artery occlusion in rats and oxygen-glucose deprivation/reoxygenation injury in SH-SY5Y cells by regulating NgR1/RhoA/ROCK2 pathway expression. Shi 2016

 

Notoginsenoside R1, and active saponin from Panax notoginseng, was shown to protect against neonatal cerebral hypoxic-ischemic injury in vivo and in vitro through estrogen receptor-dependent activation of endoplasmic reticulum stress pathways. Wang 2016

 

Oral administration of Panax notoginseng saponins provided protection against vascular dysfunction in mesenteric arteries of rats with induced metabolic syndrome, lowering blood pressure and increasing relaxation and expression of soluble guanylyl cyclase protein in arteries. Wu 2016

 

Notoginsenoside R1, a saponin isolated from Panax notoginseng, exhibited a pro-angiogenic effect in a pharmacological-induced blood vessel loss model of zebrafish, possibly via activation of the VEGF-KDR/Flk-1 and PI3K-Akt-eNOS signaling pathways. Yang 2016

 

Panax nototinseng flower saponins induced ~3-fold upregulation of VEGF mRNA expression and a concomitant increase in blood vessel density in the peri-infarct area of myocardial infarction rats and partially restored defective intersegmental vessels in vascular insufficiency zebrafish larvae. Yang 2016

 

Panax notoginseng was shown to promote significant recovery of hind-limb motor function after spinal cord injury in rats. [Article in Chinese] Yang 2016

 

Topically applied Notoginsenoside Ft1, an active saponin from Panax notogisneng, accelerated diabetic wound healing in mice by orchestrating multiple processes, including promoting fibroblast proliferation, enhancing angiogenesis, and attenuating inflammatory response. Zhang 2016

 

Oral administration for 12 weeks of Panax notoginseng saponins mitigated estrogen deficiency-induced deterioration of trabecular microarchitecture and significantly suppressed marrow adipogenesis in ovariectomized rats. Fan 2015

 

Panax notoginseng polysaccharides exhibited little scavenging effect of reactive oxygen species in vitro but significantly extended the normal lifespan and increased thermal tolerance of Caenorhabditis elegans, possibly due to increased antioxidant enzyme activities. Feng

 

Panax notoginseng significantly inhibited transforming growth factor beta, connective tissue growth factor, and monocyte chemoattractant protein in peritoneal fibrosis rats, as well as ameliorated pathological damage, including extracellular matrix deposition, vascularization, and fibroblast. Hu 2015

 

Oral administration for 3 months of notoginsenoside R1, a saponin in Panax notoginseng, was shown to provide a protective effect in Alzheimer's disease mice, at least in part through enhancement of β-amyloid protein degradation, increased PPARγ, and up-regulation of insulin degrading enzyme. Li 2015

 

Intravenous administration of ginsenoside Rg1, an active saponin from Panax notoginseng, provide neuro-protection against middle cerebral artery occlusion-induced transient focal cerebral ischemic injury in rats, significantly decreasing neurological scores and infarct volume. Lin 2015

 

Panax notoginsenosides significantly protected against cisplatin-induced nephrotoxicity in rats, decreasing blood BUN and Scr, attenuating renal histopathological changes and mitochondrial renal cell damage, and increasing mitochondria autophagosome in renal tubular epithelial cells. Liu 2015

 

UPLC/Q-TOFMS-based metabolomics showed Panax notoginseng saponins to provide protection against chronic alcohol-induced liver injury in rats, partially or nearly reversing alcohol-induced changes in hepatic biomarkers, except hexanoylglycine. Liu 2015

 

Panax notoginseng saponins were found to amelioratedcoxsackievirus B3-induced myocarditis in mice, decreasing the viral messenger RNA (mRNA) expression and enhancing activation of the cystathionine-γ-lyase/hydrogen sulfide pathway. Pan 2015

 

Panax notoginseng saponins exhibited a protective effect against early steroid-induced osteonecrosis of the femoral head in rabbits, including improving MRI and pathological changes, via antioxidant activity. Qiang 2015

 

Oral administration for 10 weeks of Panax notoginseng saponins inhibited atherosclerotic plaque angiogenesis induced by a high-fat diet in mice by down-regulating vascular endothelial growth factor and nicotinamide adenine dinucleotide phosphate oxidase subunit 4 expression. Qiao 2015

 

An arabinogalactan from Panax notoginseng flowers were found to inhibit microvessel formation in BxPC-3 pancreatic cancer cell xenograft tumors in nude mice by inhibiting BMP2/Smad1/5/8/Id1 signaling. Wang 2015

 

Panax notoginseng saponins improved hind-limb recovery after spinal cord transection in rats by upregulating expression of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Wang 2015

 

Xueshuantong for Injection, a Chinese materia medica product consisting of Panax notoginseng saponins, protected against ischemia injury in transient and permanent middle cerebral artery occlusion-induced acute ischemia/reperfusion rats via attenuating the Prx6-TLR4 pathway. Wang 2015

 

Panax notoginseng saponins significantly increased bone mineral densities in irradiated mice, attenuating inflammation and increasing blood serum AKP activity, mRNA levels of RUNX2 and osteoprotegerin, and the numbers of CFU-Fs formed by bone marrow cells. Wenxi 2015

 

Total Panax notoginseng saponins exhibited a protective effect against steroid-induced avascular necrosis of the femoral head in vivo, an effect associated with the upregulation of VEGF-A and the inhibition of apoptosis and Caspase-3 activation. Yuan 2015

 

Notoginsenosdide R1, an active saponin from Panax notoginseng, attenuated dextran sulfate sodium-induced experimental inflammatory bowel disease in mice via the activation of intestinal pregnane X receptor signaling. Zhang

 

Administration of ginsenoside Rb1, an active saponin from Panax notoginseng, attenuated angiotensin II-induced abdominal aortic aneurysm in mice, significantly reducing incidence and mortality, via inactivation of the JNK and p38 signaling pathways. Zhang 2015

 

Panax notoginseng saponins injection was found to prevent hypoxia in a rat model of pulmonary hypertension, at least in part by regulating expression of the p38MAPK pathway. Zhao 2015

 

Panax notoginseng saponins ameliorated oleic acid- and lipopolysaccharide‑induced acute lung injury in rats, possibly restoring αENaC mRNA and protein expression via anti-inflammatory effects. Chen 2014

 

Panax notoginseng modulated protein and genes expressions involved with α and β secretase, thereby increasing α-secretase activity and reducing β-secretase activity in Aβ deposition dynamics in senescence accelerated mice. Huang 2014

 

Oral administration of dencichine from Panax notoginseng root exhibited a hemostatic effect in mice via AMPA receptors on platelets, facilitating the coagulation cascade in a paracrine fashion by controlling platelet cytosolic calcium influx, cAMP production, and TXA₂ release. Huang 2014

 

Pre-administration of Panax notoginseng polysaccharides provided a neuroprotective effect against focal cerebral ischemia/reperfusion injury in mice, significantly reducing neurological deficits, infarct volumes, cerebral edema, and neuronal death caused by middle cerebral artery occlusion. Jia 2014

 

Panax notoginseng saponins was shown to improve erectile function in diabetic rats with erectile dysfunction, an effect associated with attenuation of oxidative stress, restoration of Akt activity, and protection of endothelial and smooth muscle cells. Li 2014

 

Intraperitoneal administration for 8 days of Panax notoginseng saponins exhibited a significant protective effect against cisplatin-induced nephrotoxicity and reduced renal tissue apoptosis via inhibiting the mitochondrial pathway in rats. Liu 2014

 

Panax notoginseng saponin injection was found to dose-dependently promote neurological functional recovery after middle cerebral artery occlusion in rats, significantly reducing expression of Nogo-A, NgR, and p75. Liu 2014

 

Intravenous administration of Panax notoginseng saponins was found to provide protection against hemorrhagic shock in rats through antioxidative effects and anti-inflammatory pathways, and possibly via intercellular adhesion molecule-1 (ICAM-1) activity. Liu 2014

 

Notoginsenoside R1, a saponin from Panax notoginseng, exhibited a protective effect against cerebral ischemia-reperfusion injury in vivo and in vitro by suppressing NADPH oxidase- and mitochondrion-derived superoxide through estrogen receptor-dependent activation of Akt/Nrf2 pathways. Meng 2014

 

Notoginsenoside Ft1, a saponin from Panax notoginseng, stimulated endothelial glucocorticoid and estrogen receptors and activated the PI3K/Akt and ERK1/2 pathways in rat mesenteric arteries, inducing vascular smooth muscle relaxation. Shen 2014

 

Pretreatment with panaxatriol, a saponin from Panax notoginseng, ameliorated acetaminophen-induced liver injury in mice by restoring thioredoxin-1 expression and inhibiting decreased pro-caspase-12 expression. Wang 2014

 

Panax notoginseng sapnonins significantly inhibited lung metastasis in both spontaneous and experimental in vivo models, as well as inhibited 4T1 tumor metastasis and dose-dependently impaired 4T1 cell viability in vitro. Wang 2014

 

Panax notoginseng was shown to dose-dependently attenuate colon length reduction and loss of body weight in azoxymethane/dextran sulfate sodium-induced colitis in mice. Wen 2014

 

Notoginsenoside R1, isolated from Panax notoginseng, attenuated hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK. Xu 2014

 

Oral administration of notoginsenoside R1, an active saponin from Panax notoginseng, improved learning performance of Alzheimer's disease mice as well as increased membrane excitability of CA1 pyramidal neurons in hippocampal slices. Yan 2014

 

Panax notoginseng and notoginsenosides Rg1, Rb1, and R1 suppressed tumor growth and attenuated myocardial ischemia in mice, decreasing expression of CD34 and vWF, reducing expression of miR-18a, and upregulating expression of miR-18a. Yang 2014

 

Ginsenosides Rg1, Rb1, Rg1/Rb1, and panax notoginsenoside significantly reduced infarction volume and alleviated neurological deficits in cerebral ischemia-reperfusion injury rats; however, neither Rg1/Rb1 nor PNS were shown to have synergistic effects. Zeng 2014

 

Panax notoginseng saponins was found to ameliorate oxidative stress and insulin resistance in high fat diet-induced nonalcoholic fatty liver disease rats. [Article in Chinese] Zhang 2014

 

Intraperitoneal administration of Panax notoginseng was shown to exhibit anti-hyperglycemic and anti-obesity activity in KK-Ay diabetic mice by improving insulin and leptin sensitivity. [Article in Chinese] Zhong 2014

 

Intraperitoneal administration of ginsenoside Rd from Panax notoginseng reduced blood-brain barrier permeability, regulated interferon-gamma secretion and interleukin-4, promoted Th2 shift, and prevented reduction of neurotrophic factor and nerve growth factor in autoimmune encephalomyelitis mice. Zhu 2014

 

Panax notoginseng aqueous extract with Radix Astragali and Radix Angelica sinensis prevented pathogenesis of diabetic retinopathy in streptozotocin-induced diabetic rats, reducing leukostasis, acellular capillaries, and vascular leakage, as well as decreased inflammatory markers in retinas. Gao 2013

 

Panax notoginseng suppressed femoral fracture-induced apoptosis in superficial cells of the renal cortex following femoral fracture in rats by down-regulating Bax expression and up-regulating Bcl-2 expression. [Article in Chinese] Gao 2013

 

Panax notoginseng saponins were shown to dose-dependently decrease the activity of BACE1 and to downregulate BACE1 protein expression in the brain of senescence accelerated-prone mice with Alzheimer's disease. [Article in Chinese] Huang 2013

 

Oral administration of Panax notoginseng saponins exhibited a protective effect against carbon tetrachloride-induced hepatic fibrosis in rats, and effecta associated with up-regulating MMP-3, inhibiting TIMP-1 expression, and improving collagen degradation. [Article in Chinese] Jiang 2013

 

Administration for 10 weeks of Panax notoginseng saponins provided a protective effect against C(Cl4)-induced liver fibrosis in rats, significantly reducing histopathological change and decreasing levels of IL-1, IL-6, NF-kappaB, TNF-alpha ,TGF-beta, and increasing IL-10. [Article in Chinese] Jiang 2013

 

Intraperitoneal adminstration of ginsenoside Rg1 from Panax notoginseng enhanced collagenic myocardium remodeling in chronic thromboembolic pulmonary hypertension rat, possibly by upregulating expression of matrix metalloproteinases-2 and -9. Li 2013

 

Panax notoginseng saponins were shown to improve erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum via attenuation of the NO/cGMP pathway. Lin 2013

 

Administration of Panax notoginseng by gastrogavage promoted fibrous repairing of subdural hematoma in chronic subdural hematoma rabbits, as well as lessened inflammation and oxidative injury of the hematoma outer membrane, effects associated with reduced expression of VEGF. Liu 2013

 

Intraperitoneal administration for 8 weeks of Panax notoginseng was shown to reduce the size of atherosclerotic plaque in apolipoprotein E knockout mice, an effect associated with endothelial progenitor cell mobilization and SDF-1α-CXCR4 interactions. Liu 2013

 

Prereatment with Panax notoginseng ginsenoside Rb1 was found to upregulate protein levels of brain-derived neurotrophic factor and downregulate Tau protein expression in an Alzheimer's disease model of the rat brain. Wang 2013

 

Administration for 28 days by nasogastric feeding of Panax notoginsenoside granules dramatically decreased the severity of lung inflammation and fibrosis in bleomycin-induced pulmonary fibrosis rats, possibly by regulating the TGF-β1/Smads signaling pathway. [Article in Chinese] Wu 2013

 

Administration for 14 weeks of Panax notoginseng root reduced TGF-beta1/Smads signaling pathway and subsequently reduced the expression of connective tissue growth factor in rats with alcohol-induced liver disease. [Article in Chinese] Zhang 2013

 

Notoginsenoside Rb3 exhibited antidepressant activity in various mouse models, an effects associated with brain-derived neurotrophic factor and monoamine neurotransmitters 5-hydroxytryptamine, dopamine, and norepinephrine. Cui 2012

 

Panax notoginseng saponins inhibited progression of atherosclerotic lesions in apolipoprotein deficient mice via antioxidant/anti-inflammatory properties, suppression of RAGE/MAPK signaling pathways, inactivation of NF-κB, and reducing the expression of pro-inflammatory factors. Dou 2012

 

Intraperitoneal administration of Panax notoginseng saponins was shown to attenuate pathological changes of atherosclerosis in rats at least partly via reciprocal regulation of lipid metabolism and inflammation by inducing liver X receptor alpha expression. Fan 2012

 

Oral pretreatment with Panax notoginseng extract or ginsenoside Rb1 and Rg1 was shown to markedly attenuate lipopolysaccharide and galactosamine-induced hepatic damage in mice. [Article in Japanese] Komatsu 2012

 

Panax notoginseng saponins exhibited a neuroprotective effect against acute spinal cord ischemia-reperfusion injury in rats, which may be mediated by anti-inflammatory, anti-edema, and anti-apoptosis activity. Ning 2012

 

Panax notoginseng extract injections dose-dependently lowered blood pressure in spontaneously hypertensive rats, while ginsenoside Rb1 and Rg1 from Panax notoginseng increased endothelial-dependent vessel dilatation in mouse coronary arteries. Pan 2012

 

Intraperitoneal pre-administration with Panax notoginseng provided protection on lung tissue in ischemia/reperfusion injury rats, possibly by suppressing JNK signaling, up-regulating the ratio of Bcl-2/Bax, and inhibiting caspase-3 dependent apoptosis. [Article in Chinese] Qiu 2012

 

Panax notoginseng was found to delay vascular aging in spontaneously hypertensive rats by inhibiting vascular smooth muscle cells proliferation via modulation of p16-cyclin D/CDK-RB pathways. [Article in Chinese] Tao 2012

 

Panax notoginseng flower extract was shown to improve the ventricular hypertrophy state in human chymase transgenic mice via regulation of the expression of TGF-β/Smad mRNA and protein in ventricular tissues. Wang 2012

 

Intragastric administration of Panax notoginseng root was shown to reduce unilateral ureteral obstruction-induced renal interstitial fibrosis in rats, improving tubulointerstitial damage and collagen matrix accumulation. [Article in Chinese} Xie 2012

 

Panax notoginseng notoginsengnosides, alone and syngergistically with salvianolic acids from Salvia militorhiza, exhibited protection against occlusion ischemia/reperfusion-induced cardiac injury in rats. Yue 2012

 

Intraperitoneal pre-administration of Panax notoginseng saponins reduced pulmonary hypertension and improved pulmonary vascular wall remodeling in rats with hypoxic hypercapnia pulmonary hypertension, possibly by inhibiting expression of p38 MAPK. [Article in Chinese] Zhu 2012

 

Panax notoginseng saponins exhibited a protective effect against ischemia-reperfusion-induced apoptosis in rats and in myocardial cells via activation of the PI3K/Akt signaling pathway. Chen 2011

 

Intraperitoneal administration of ginsenoside-Rd prevented development of apolipoprotein E deficieny-induced atherosclerosis in mice possibly by inhibiting Ca(2+) influx through voltage-independent Ca(2+) channels and reductions of ox-LDL uptake and cholesterol accumulation. Li 2011

 

Panaxatriol saponins from Panax notoginseng provided neuroprotection against loss of dopaminergic neurons and behavioral impairment caused by MPTP in vivo, enhancing antioxidant activity, acting as neurotrophic factor, modulating inflammation, and inhibiting apoptosis. Luo 2011

 

Panax notoginseng orally administered in the early fibrotic stage was shown to attenuate bleomycin-induced pulmonary fibrosis in mice, significantly decreasing inflammatory cell infiltrates; fibrosis scores; and TNF-α, TGF-β, IL-1β, and IL-6 levels in bronchoalveolar lavage fluid. Tsai 2011

 

Panax notoginseng was shown to exhibit a protective effect on the renal tissues of diabetic rats, possibly by inhibiting the expression of transforming growth factor β1 and enhancing the expression of Smad7. Tu 2011

 

Administration fo Panax notoginseng for 4 weeks was shown to significantly improve lipid profiles, inhibit lipid peroxidation, and increase the activity of antioxidant enzymes in high-fat diet hyperlipidemic rats. Xia 2011

 

Saponins from the caudex and leaf of Panax notoginseng were shown to exhibit antidepressant effects in mice, possibly by increasing the levels of 5-hydroxytryptamine, dopamine, and noradrenaline and reducing intracellular Ca(2+). Xiang 2011

 

Panax notoginseng total saponins were found to inhibit in glutathione-s-transferasethe mouse liver. Kinetics studies showed inhibition to belong to the mix-type with reduced glutathione and 1-chloro-2,4-dinitrobenzene substrate. [Article in Chinese] Yang 2011

 

Panax notoginseng saponins were shown to inhibit zymosan A-induced atherosclerosis in rats by suppressing integrin expression, FAK activation, and NF-κB translocation. Yuan 2011

 

Panax notoginseng injection was shown to enhance tendon-bone healing in bone tunnel in rabbits, promoting the connection between tendon and bone via induction of fibroblast proliferation and bone formation. [Article in Chinese] Zhang 2011

 

Intraperitoneal administration of Panax notoginseng was shown to mobilize homing of C-kit+ bone mesenchymal stem cells from the marrow into the peripheral blood and promoted "homing" activity in an acute myocardial infraction mouse model Zhang 2011

 

Panax notoginseng was found to alleviate pathological changes in the small intestine and immune organs of rats with severe acute pancreatitis. Zhang 2011

 

Intragastric administration for 4 weeks of Panax notoginseng dose dependently improved learning and memory of senescence accelerated mice, possibly by down-regulating expression of the APP gene at the transcriptional level in the brain. [Article in Chinese] Zhong 2011

 

Panax notoginseng root extract up-regulated protein and mRNA expressions of VEGFR-2 and HIF-1 alpha and increased MVD in ischemic myocardium to improve myocardial ischemia in rats with acute myocardial infarction. [Article in Chinese] DU 2010

 

Ginsenoside-Rg1 from Panax notoginseng exhibited a significant protective effect against thioacetamide-induced hepatic fibrosis in rats, markedly suppressing serum levels of fibrotic markers and hepatic hydroxyproline content. Geng 2010

 

Panax notoginseng saponins reduced pathological injury of cardiac myocytes in myocardial ischemia and cardiac muscle ventricular remodelling in rats by stimulating ACE2 to inhibit the expression of TNF-alpha and enhance antioxidant capacity. [Article in Chinese] Guo 2010

 

Panax notoginseng saponins and astragalosides exhibited a dose-dependent synergistic effect against ischemia-reperfusion injury in mice, possibly by attenuating matrix metalloproteinases-9 and tissue inhibitor of metalloproteinase-1 expression. [Article in Chinese] Huang 2010

 

Oral administration of Panax notoginseng for 3 weeks was shown to provide a protective effect against poloxamer-407-induced hyperlipidemia in rats, significantly lowering serum total cholesterol and triglyceride levels and inflammation. Joo 2010

 

Panax notoginseng dose dependently inhibited contraction of small intestine smooth muscle in rabbits, an effect associated with increased NO concentration and inhibiting extracellular Ca2+ inflow. [Article in Chinese] Li 2010

 

Notoginsenoside R1 from Panax notoginseng was shown to improve renal function in ischemia/reperfusion injury rats, an effect associated with significant reduction of cell apoptosis and inflammatory responses possibly related to p38 and nuclear factor kappaB inhibition. Liu 2010

 

Intragastric administration of Panax notoginseng saponins attenuated zymosan-accelerated atherogenesis in rabbits via anti-inflammatory activity and regulation of the blood lipid profile. Liu 2010

 

Panaxatriol saponins from Panax notoginseng was shown to induce thioredoxin-1 expression mice and in vitro and to attenuate 1-methyl-4-phenylpyridinium ion-induced cell death in PC12 cells, which may be beneficial in neurodegenerative diseases including Parkinson's disease. Luo 2010

 

Oral administration of Panax notoginseng for 13 weeks dose dependently alleviated ovariectomy-induced osteoporosis in rats, enhancing bone mineral density and bone strength and preventing the deterioration of trabecular microarchitecture without a hyperplastic effect on uterus. Shen 2010

 

Intragastric administration of Panax notoginseng saponins exhibited a regulatory effect on the immune-neuroendocrine network disruption of rats in experimental navigation and intensive exercise. [Article in Chinese] Wang 2010

 

Oral administration of Panax notoginseng saponins inhibited vessel restenosis after aortic intimal hyperplasia injury in rats, possibly by blocking excessive proliferation of vascular smooth muscle cells, reduction of ECM protein deposition in the endometrium, and degradation of ECM protein. Wu 2010

 

Intraperitoneal administration of Panax notoginseng, as well as notoginsenoside RG1, was shown to exhibit antihyperglycemic and anti-obesity activity in KK/Ay mice by improving insulin and leptin sensitivity. Yang 2010

 

Oral administration of dried Panax notoginseng root aqueous extract in combination with Salvia miltiorrhiza exhibited an antihypertensive effect in spontaneously hypertensive rats possibly by altering the arterial MR, not by direct inhibition of L-type Ca(2+) channels or by ACE inhibition. Baek 2009

 

Ginsenoside Rd from Panax notoginseng attenuated basilar hypertensive cerebrovascular remodeling in hypertensive rats without affecting systemic blood pressure, an effect associated with voltage-independent Ca(2+) entry and BAVSMC proliferation but not with VDCC-mediated Ca(2+) entry. Cai 2009

 

Panax notoginseng saponins dose-dependently inhibited expression of TNF-alpha and MMP-2, enhanced left ventricular systolic and diastolic functions, decreased peripheral resistance, and improved cardiac function of rats with post-myocardial infarction. [Article in Chinese] Guo 2009

 

Oral administration of raw and steamed Panax notoginseng extract prolonged bleeding time in rats and inhibited platelet aggregation and plasma coagulation in vitro; steamed extract exhibited more potent antiplatelet and anticoagulant effect than raw extract and compared to other Panax species. Lau 2009

 

Intraperitoneal administration of Panax notoginseng total saponins modulated the expression of caspases and attenuated apoptosis in rats following transient middle cerebral artery occlusion-induced focal cerebral ischemia-reperfusion injury. Li 2009

 

Oral administration of Panax notoginseng total saponins for 12 weeks was shown to prevent atherosclerosis in apolipoprotein E-knockout mice by lowering serum lipid levels and regulating vascular cell differentiation antigen 40 and matrix metalloproteinase 9 expression. Liu 2009

 

Intragastric administration of Panax notoginseng saponins for 4 weeks was found to up-regulate syp gene expression at the transcriptional level in the brain of senescence accelerated mice; no significant difference was observed in tau mRNA content. [Article in Chinese] Lv 2009

 

Panax notoginseng saponins exhibited an immunoregulatory effect against carbon tetrachloride-induced hepatic fibrosis rats, significantly attenuating hepatic fibrosis, collagen area, and collagen area percent in liver tissue and reducing levels of serum TGF-beta1, TNF-alpha, and IL-6. Peng 2009

 

Intravenous pre-administration of Panax notoginseng saponins provided a protective effect against ischemia-reperfusion-induced acute lung injury in rats via antioxidant and anti-inflammatory effects. Rong 2009

 

Intraperitoneal administration of Panax notoginseng 2 hours after onset provided neuroprotection in artery-occlusion-induced brain ischemia in rats, effects associated with anti-inflammatory and microglial inhibitory activity. Son 2009

 

Panax notoginseng saponins was shown to significantly inhibit intima hyperplasia in aortic intima injury-induced rats by inhibiting proliferation of vascular smooth muscle cell. [Article in Chinese] Wang 2009

 

Oral administration of Panax notoginseng saponins was found to effect the expression of specific cytochrome P-450 genes and glutathione S-transferase genes in the lung tissues of rats, although others were not affected. [Article in Chinese] Yang 2009

 

Intraperitoneal administration of Panax notoginseng saponins for 30 days exhibited dose-dependent significant anti-diabetic, anti-obesity, and renoprotective effects in type 2 diabetic mice, including preventing development of glomerular lesions. [Article in Chinese] Yang 2009

 

Panax notoginseng provided a protective effect against ligation-induced acute myocardial infarction in rats, increasing mobilization efficiency of bone marrow stem cells, efferens efficiency of bone marrow stem cells, and number of peripheral blood stem cells. [Article in Chinese] Zhang 2009

 

Panax notoginseng saponins were found to reduce the amount of Abeta(1-40) and Abeta(1-42) protein in parietal cortex and hippocampus of SAMP8 mice. [Article in Chinese] Zhong 2009

 

Intraperitoneal administration of saponins from Panax notoginseng root significantly lowered fasting blood glucose; improved glucose tolerance; and decreased serum insulin resistance index, triglycerides, and development of glomerular lesions in KK-Ay mice. Chen 2008

 

Oral administration of Panax notoginseng attenuated the reduction in learning and memory functions in cerebral ischemia-reperfusion injured rats at least in part by increasing levels of activated microglia and brain derivative neurotrophin factor. Chuang 2008

 

Panax notoginseng saponins were shown to provide a protective effect on gastric mucosa of water immersion stress-induced rats by up-regulating melatonin receptor expression associated with promoting melatonin secretion or increasing binding capacity of melatonin to its receptor. [Article in Chinese] Deng 2008

 

Intraperitoneal administration of ginsenoside Rg1 from Panax notoginseng significantly inhibited renal interstitial fibrosis in rats with unilateral ureteral obstruction, partly blocking tubular epithelial-myofibroblast transition via suppressing the expression of thrombospondin-1. Xie 2008

 

Post-treatment with Panax notoginseng saponins attenuated continuous lipopolysaccharide-induced microcirculatory disturbance in rat mesentery by reducing adherent leukocytes, degranulation of mast cells, expression of CD11b, and concentration of IL-6, INF-gamma. Yang 2008

 

Intraperitoneal administration of Panax notoginseng markedly reduced total serum cholesterol, triglycerides, and blood viscosity in rats, effects associated with anti-inflammatory activity and modulation of the NF-kappaB signalling pathway. Zhang 2008

 

Oral administration of Panax notoginseng n-butanol extract was shown to delay the onset and progression of collagen-induced arthritis in mice, effects associated with inhibition of inflammatory markers and inhibition of the activation of NF-kappaB, ERK, p38, and JNK pathways. Chang 2007

 

Oral administration of Panax notoginseng n-butanol extract dose-dependently prevented accumulation of abnormal lipids in hyperlipidemic rats by functioning as a dual liver X receptor alpha and farnesoid X receptor alpha agonist. Ji 2007

 

Panax notoginseng reduced carageenan-induced mouse paw edema via anti-inflammatory activity related to inhibition of neutrophil functions and nitric oxide (NO) and prostaglandin (PG)E2 production, possibly due to decreased expression of iNOS and COX-2. Jin 2007

 

Panax notoginseng saponins attenuated the effects of lipopolysaccharide-induced microcirculatory disturbance and subsequent leukocyte adhesion to the venular wall, mast cell degranulation, red blood cell viscocity, and the release of cytokines microcirculatory in rat mesentery. Sun 2007

 

Panax notoginseng saponins exhibited a protective effect against nylon monofilament-induced cerebral ischemia reperfusion in rats, inhibiting mRNA expression of caspase-3, IL-1 beta, and its correlative inflammatory factors in brain tissue. [Article in Chinese] Tang 2007

 

Panax notoginseng ethanolic extract was shown to dose-dependently improve the quality of life and to inhibit liver metastasis of B16 melanoma grafted mice. [Article in Chinese] Yang 2007

 

Notoginsenoside Rd, isolated from Panax notoginseng, exhibited immunological adjuvant activity in ovalbumin-sensitized mice via eliciting Th1 and Th2 immune response and regulating production and gene expression of Th1 cytokines and Th2 cytokines. Yang 2007

 

Ginsenoside Rh4, a saponin isolated from the roots of Panax notoginseng, was shown to exhibit a dose-dependent adjuvant effect on specific antibody and cellular response to ovalbumin in mice with low or non-hemolytic effect. Yang 2007

 

Panax notoginseng saponins were shown to dose-dependently facilitate long-term potentiation in the CA1 region of the rat hippocampus as observed in excitatory postsynaptic currents, an effect which may contribute to learning and memory. [Article in Chinese] Zhou 2007

 

Panax notoginseng stem and leaf saponins attenuated arterial ligation-induced myocardial ischemia and infarction injury in anesthetized dogs, possibly by inhibiting ET and TXA2 release, increasing myocardial blood flow, and improving damaged cardiac function. [Article in Chinese] Fu 2006

 

Notoginsengoside K, an active saponin from Panax notoginseng root extract, was shown to exhibit slight hemolytic activity and a significant adjuvant effect on specific antibody and cellular response against ovalbumin in mice. Qin 2006

 

The number, length, and position of sugar side chains and the type of glucosyl group in the structure of protopanaxatriol-type saponins from Panax notoginseng roots was found to affect haemolytic activities and adjuvant potentials in mice, as well as to have significant effects on immune responses. Sun 2006

 

Ginsenoside Re and notoginsenoside R1 from Panax notoginseng exhibited slight hemolytic activity and significant adjuvant effect on specific antibody and cellular immune responses against ovalbumin in mice. Sun 2006

 

Panax notoginseng saponins exhibited an anti-inflammatory effect in mice by inhibiting burn-induced NF-kappaB activity and tumor necrosis factor-alpha mRNA expression. Wang 2006

 

Panax notoginseng powder exhibited hemostatic activity when used to staunch bleeding of transected tail sections of rats compared to placebo. Fan 2005

 

Intraperitoneal administration of Panax notoginseng saponins dose-dependently attenuated ischemia-induced brain inflammation in rats by inhibiting neutrophil infiltration and the expression of intercellular adhesion molecule-1 (ICAM-1). [Article in Chinese] He 2005

 

Panax notoginseng was shown to attenuate gut ischemia/reperfusion-induced hepatic microvascular dysfunction, TNF-alpha production, and hepatocellular damage in the early phase in rats via enhancement of NO production and anti-inflammatory activity. Park 2005

 

Panax notoginsneg exhibited an ameliorative effect on the unilateral ureteral obstruction-induced fibrotic process of the renal interstitium in rats by blocking tubular epithelial-myofibroblast transdifferentiation. [Article in Chinese] Su 2005

 

Four protopanaxadiol-type saponins from the roots of Panax notoginseng were evaluated for hemolytic and adjuvant potentials on cellular and humoral immune responses against ovalbumin-induced splenocyte proliferation in ICR mice, with ginsenoside Rd exhibiting the highest adjuvant activity. Sun 2005

 

Three dammarane saponins isolated and characterized in the extract fraction of Panax notoginseng were shown to exhibit immunological-adjuvant properties in the humoral immune responses of ICR mice against ovalbumin. Sun 2005

 

Panax notoginseng extract administered intranasally dose-dependently reduced myocardial infarct size induced by occlusion of the left coronary artery and alleviated cerebral edema and stroke symptoms induced by occlusion of bilateral common carotid artery in gerbils. [Article in Chnese] Wu 2005

 

Panax notoginseng saponin preconditioning exhibited a protective effect against liver grafts from ischemia reperfusion injury effectively in rat orthotopic liver transplants via an antiapoptotic pathway involving inhibition of TNF-alpha and Caspase-3 and upregulation of Bcl-2. Zhang 2005

 

Panax notoginseng saponins wee shown to provide protective against the pathogenesis of cholinergic neuron legion in Alzheimer's disease rats by reducing the level of choline acetyltransferase and number of cholinergic neurons. [Article in Chinese] Zhong 2005

 

Panax notoginseng was shown to provide a protective effect against D-galactose/ibotenic acid-induced synaptophysin protein brain lesions in Alzheimer's disease rats. [Article in Chinese] Zhong 2005

 

Panax notoginseng saponins exhibited an antirestenotic effect against balloon endothelial denudation injury in rabbits by promoting endothelial regeneration and thickening, which was associated with regulation of VEGF and MMP-2 expression. Chen 2004

 

The optimal time for administration of Panax notoginseng saponins for therapeutic effect against focal cerebral ischemia/reperfusion injury in rats was found to be 3-4 hrs after onset of ischemia, with the therapeutic window no more than 5 hrs after onset. [Article in Chinese] He 2004

 

Intraperitoneal administration of Panax notoginseng saponins for 5 days was found to prevent acute oxygen toxicity induced by prolonged exposure to hyperbaric oxygen in mice, an effect associated with antioxidant activities. [Article in Chinese] Li 2004

 

Panax notoginseng dose-dependently enhanced splenocyte proliferation in ovalbumin(OVA)-immunized mice, significantly increasing OVA-specific IgG, IgG1, and IgG2b serum antibody levels. Sun 2004

 

Panax notoginseng saponins was shown to dose-dependently inhibit IL-1 alpha-induced transdifferentiation of NRK52E tubular epithelial cells and secretion of extracellular matrix in rats. [Article in Chinese] Wang 2004

 

Oral administration of Panax notoginseng pulverized root for 28 days resulted in a moderate, non dose-dependent decrease in plasma lipid levels and a significant reduction in fibrinogenaemia in high-fat diet rats. Cicero 2003

 

Panax notoginseng hot water extract was shown to ameliorate the rise in serum sGOT and sGPT induced by chronic ethanol administration in mice, possibly via antioxidant activity. Lin 2003

 

Administration of Panax notoginseng for 12 weeks significantly increased gastric secretions and gastric mucosal blood flow in rats with precancerous stomach lesions, effects associated with antioxidant activity. Shi 2003

 

Panax notoginseng saponins were shown to exhibit immunologic adjuvant activity and a low-hemolytic effect in mice subcutaneously sensitized to ovalbumin. Sun 2003

 

Effects of panax notoginseng saponins on the expression of tumor necrosis factor alpha and secretion phospholipase A2 in rats with liver fibrosis. [No abstract] [Article in Chinese] Wu 2003

 

Itraperitoneal administration of Panax notoginseng saponins dose-dependently increased myocardial Gsalpha mRNA expression and AC activity, cAMP content, and ATPase activities in the myocardium of rats subjected to severe scalding burns. Zhang 2003

 

Panax notoginseng saponins exhibited a protective effect against focal cerebral ischemia in rats by alleviating cerebral edema, up-regulating the expression of heat shock proteins, down-regulating transferrin, and maintaining blood-brain barrier. [Article in Chinese] Yao 2002

 

Alcoholic extract of Panax notoginseng was shown to reduce bleeding time more effectively than hydrophilic or lipophilic extracts in a hemorrhagic rat model. White 2001

 

Oral administration of Panax notoginseng for 10 days was found to significantly reduce duration and number of grooming episodes and to increase inner crossings in open field spontaneous behaviors in rats. Feeding behavior appeared not to be affected by treatment. Cicero 2000

 

Oral administration of Panax notoginseng for one week was found to improve scopolamine-induced learning and memory deficit in rats. Hsieh 2000

 

Panax notoginseng saponins were found to dose-dependently inhibit cyclopiazonic acid-induced endothelium-dependent relaxation in rat aorta by preventing the elevation of cytosolic Ca2+, which is required for activation of NO generation and release from vascular endothelial cells. Kwan 2000

 

Pretreatment with Panax notoginseng saponins reduced cisplatin-induced nephrotoxicity in mice, an effect associated with reduced cytosolic free [Ca2+]i overload and decreased formations of DNA interstrand cross-link and DNA-protein cross-link. Liu 2000

 

Panax notoginseng powder and a saponin extract of notoginseng both exhibited hemostatic effects when applied externally to ligated rat tail wounds; no differences were found between the notoginseng and the saponin extract groups. White 2000

 

Panax notoginseng saponins were found to block Ca(2+)-overload and Ca(2+)-CaM complex production in nerve cell after cranial cerebral injury in rabbits. [Article in Chinese] Han 1999

 

Intraperitoneal administration of Panax notoginseng saponins was found to improve early postburn cardiac function in rats. Huang 1999

 

Panax notoginseng root extract exhibited significant anti-tumor activity against two-stage carcinogenesis of mouse skin tumors. Konoshima 1999

 

Panax notoginseng saponins exhibited a dose-dependent anti-inflammatory effect against carageenan-induced air-pouch acute inflammation in rats via inhibition of intracellular free calcium concentration in neutrophils and phospholipase A2 and reduction of dinoprostone content. Li 1999

 

Panax notoginseng saponins were shown to dilate microvessels and increase cerebral blood flow in anesthetized mice's meninges, as well as to protect cultured rat cortical neurons from glutamate neurotoxicity. [Article in Chinese] Ma 1999

 

Intraperitoneal administration of Panax notoginseng aqueous extract did not attenuate adjuvant-induced persistent hindpaw inflammation and hyperalgesia in rats. Wei 1999

 

Panax notoginseng saponins increased calcium pump activity on the membrane of sarcoplasmic reticulum, decreased myocardial intracellular Ca2+, and reduced the mass of the left ventricular muscle in spontaneously hypertensive rats. [Article in Chinese] Feng 1998

 

Acute intraperitoneal administration of Panax notoginseng saponins was shown to inhibit Ca2+ uptake in mouse synaptosomes. Ma 1997

 

Panax notoginseng was shown to alleviate lipid peroxidation-induced late hemorrhagic injury in rabbits, with Salvia miltiorrhiza and ligustrazine exhibiting an additive effect. [Article in Chinese] Wang 1997

 

Panax notoginseng methanol and water extracts showed significant activity in carbon tetrachloride-induced liver injury in rats, while ginsenosides-Re and -Rgl exhibited a hepatoprotective effect against D-galactos-amine/lipopolysaccharide-induced liver injury in mice. Prasain 1996

 

Intravenous administration of Rg1, a saponin fraction from Panax notoginseng, was shown to prolong sinus node recovery time and ventricular refractoriness and repolarization, as well as to increase ventricular fibrillation threshold, in the dog heart. Wu 1995

 

Panax notoginseng saponins were shown to inhibit alpha-adrenoceptor agonists-induced contractile responses and Ca2+ entry in dog mesenteric arteries and saphenous veins via the receptor-operated Ca2+ channel. Guan 1994

 

Intraperitoneal administration of Panax notoginseng total saponins, alone and combined with electroacupuncture, was shown to exhibit anti-inflammatory, analgesic and immunomodulatory activity against paraffin-induced pain and inflammation in mice. [Article in Chinese] Wang 1994

 

Panaxatriol saponins from Panax notoginseng were found to increase the duration of action potential in isolated sheep Purkinje fibers by blocking the delayed rectifier potassium channel. [Article in Chinese] Li 1993

 

Oral administration of Panax notoginseng total saponins for 7 days was shown to lower total blood glucose and total blood cholesterol in high lipid rats and quails. [Article in Chinese] Xu 1993

 

Panaatriol saponins isolated from Panax notoginseng exhibited anti-arrhythmic activities on coronary artery ligation-induced ischemic and reperfused arrhythmias in rats, including reduced size of myocardial infarct. [Article in Chinese] Gao 1992

 

Alcoholic extract of Panax notoginseng artificial tissue culture increased outflow of coronary vessels, decreased heart rate, inhibited constriction of aortic strip stimulated by nor-epinephrine, and relaxed spasmodic constriction of ileum smooth muscles in anoxic mice. [Article in Chinese] Hu 1992

 

Intravenous administration of Panax notoginseng saponins was shown to reduce mean blood pressure in urethane-anesthetized New Zealand rabbits and in sodium pentobarbital-anesthetized Wistar rats; effects on cerebral blood flow were animal-specific. [Article in Chinese] Wu 1992

 

Sanchinoside C1 (ginsenoside Rg1), a saponin from Panax notoginseng, was shown to dose-dependently lower plasma glucose in alloxan-induced diabetic mice; no synergism or antagonism between sanchinoside C1 and insulin was observed. [Article in Chinese] Gong 1991

 

Pretreatment with a traditional Chinese herbal formulation, including Panax notoginseng, was shown to provide a protective effect against incomplete cerebral ischemia in rats via decreasing lipid peroxidation. Leung 1991

 

Pretreatment with Panax notoginseng total saponins and purified ginsenosides Rb1 and Rg1 prevented mycardial infarction induced by ischemia/reperfusion injury in rats, an effect associated with inhibition of lipid peroxidation. [Article in Chinese] Li 1990

 

Oral administration of Panax notoginseng was shown to exhibit anti-atherosclerotic activity in rabbits by restoring normal prostacyclin and thromboxane A2 levels. [Article in Chinese] Shi 1990

 

Total Panax notoginseng saponins were found to reduce guinea pig papillary muscle contractility via a selective blocking effect on calcium channels. [Article in Chinese] Xiong 1989

 

Ginsenoside Rb1, a saponin from Panax notoginseng, was shown to significantly decrease contractile force in guinea pig papillary muscles, exhibited a blocking effect on calcium channels; Rg1 was found not to be effective. [Article in Chinese] Xiong 1989

 

Effects of Panax notoginseng saponins on hemorrhagic shock in rabbits. [No abstract] [Article in Chinese] Li 1988

 

Pananx notoginseng extract was shown to suppress systemic blood pressure in albino rats and rabbits, exhibiting multiple effector sites in the cardiovascular system via increased utilization of extracellular calcium ions. Lei 1986

 

Panax notoginseng saponins was found to increase height and frequency of cardiac monophasic action potentials of rabbit hearts and to inhibit the automaticity of isolated guinea pig right atria and the contractility of the left atria. [Article in Chinese] Chen 1992