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Adverse Effects & Toxicity

June 08, 2020

Adverse Effects & Toxicity from


A novel antitumor agent, 25-methoxydammarane-3, 12, 20-triol from Panax notoginseng, was well tolerated and no adverse effects were detected in Sprague-Dawley rats at any dose level (150, 300 and 600 mg/kg) when orally administered for 92 consecutive days. Li 2016

Panax notoginseng saponins injection was found to induce a dose-dependent pseadoanaphylactoid reaction in mice, possibly related to histamine, VEGF, TNF-α, IL-6, and IL-10. [Article in Chinese] Yu 2015

Salvianolic acid B in combination with ginsenoside Rg1, an active saponin from Panax notoginseng, was determined to be safe in acute toxicity and seven-day repeated dose toxicity studies in mice. Zhao 2015

Four elderly Chinese patients exhibited severe skin eruption reportedly induced by Panax notoginseng saponins injection. Symptoms included pustules, fever, and elevated circulating neutrophil counts, which required high-dose, long-term glucocorticoid therapy. Yin 2014

A rapid ultra performance liquid chromatography coupled with photo diode array detection (UPLC-PDA) method was developed to simultaneously determine notoginsenoside R1, ginsenoside Rg1, Re, Rf, Rb1, Rg2, Rc, Rb2, Rb3, Rd, and Rg3 from Panax notoginseng. Guan 2007

Panax notoginseng saponins increased brain edema and nerve defect score when injected into the brain at the early stage of cerebral hemorrhage in rats with hypertension and cerebral hemorrhage induced by collagenase. [Article in Chinese] Nie 2006

The neuroexcitotoxic nonprotein amino acid beta-N-oxalo-L-alpha,beta-diaminopropionic acid was isolated and characterized from Panax notoginseng root. Both beta-N-ODAP and alpha-N-ODAP were shown to be easily converted into their isomers at higher temperature or in acidic and basic solution. Long 1996